Immunotherapy in SMARCB1 (INI-1)-deficient sinonasal carcinoma: Two case reports

被引:4
作者
Zhang, Lu [1 ]
Gao, Ai-Xin [2 ]
He, Yu-Lu [3 ]
Xu, Ming-Jin [1 ]
Lu, Hai-Jun [4 ]
机构
[1] Qingdao Univ, Dept Oncol, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China
[2] Qingdao Univ, Dept Radiol, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China
[3] Peking Univ Peoples Hosp, Dept Pathol, Qingdao 266003, Shandong, Peoples R China
[4] Qingdao Univ, Radiat Oncol, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China
关键词
SMARCB1; INI-1; Sinonasal carcinoma; Gene deficient; Immunotherapy; Surgery; Case report;
D O I
10.12998/wjcc.v11.i32.7911
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND SMARCB1/INI-1 deficient sinonasal carcinoma (SDSC) is a rare subset of sinonasal undifferentiated carcinoma with a poor prognosis. Here, we present two case reports of SDSC patients. We also review the literature on this tumor. This is the first published report of SDSC treatment with immunotherapy.CASE SUMMARY Here we present two patient cases of SDSC in which initial consultation and diagnosis were complicated but SDSC was ultimately diagnosed. One patient received a traditional treatment of surgery and adjuvant chemoradiotherapy, while the other patient received additional immunotherapy; the prognoses of these two patients differed. We review previous diagnostic literature reports and SDSC treatments and provide a unique perspective on this rare type of tumor.CONCLUSION SDSC is a rare, diagnostically challenging carcinoma with a consistently poor prognosis, early distant metastases, and frequent recurrence. Timely diagnosis and intervention are critical for treatment, for which the standard of care is surgery followed by adjuvant chemoradiotherapy, though immunotherapy may be an effective new treatment for SDSC.
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页数:10
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