SMARCB1;
INI-1;
Sinonasal carcinoma;
Gene deficient;
Immunotherapy;
Surgery;
Case report;
D O I:
10.12998/wjcc.v11.i32.7911
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
BACKGROUND SMARCB1/INI-1 deficient sinonasal carcinoma (SDSC) is a rare subset of sinonasal undifferentiated carcinoma with a poor prognosis. Here, we present two case reports of SDSC patients. We also review the literature on this tumor. This is the first published report of SDSC treatment with immunotherapy.CASE SUMMARY Here we present two patient cases of SDSC in which initial consultation and diagnosis were complicated but SDSC was ultimately diagnosed. One patient received a traditional treatment of surgery and adjuvant chemoradiotherapy, while the other patient received additional immunotherapy; the prognoses of these two patients differed. We review previous diagnostic literature reports and SDSC treatments and provide a unique perspective on this rare type of tumor.CONCLUSION SDSC is a rare, diagnostically challenging carcinoma with a consistently poor prognosis, early distant metastases, and frequent recurrence. Timely diagnosis and intervention are critical for treatment, for which the standard of care is surgery followed by adjuvant chemoradiotherapy, though immunotherapy may be an effective new treatment for SDSC.
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Alimova, Irina
;
Pierce, Angela
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Pierce, Angela
;
Danis, Etienne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Danis, Etienne
;
Donson, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Donson, Andrew
;
Birks, Diane K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Birks, Diane K.
;
Griesinger, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Griesinger, Andrea
;
Foreman, Nicholas K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn Pediat Brain Tumor Res Program, Aurora, CO 80045 USA
Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Foreman, Nicholas K.
;
Santi, Mariarita
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Univ Penn Perelman, Sch Med, Philadelphia, PA 19104 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Santi, Mariarita
;
Soucek, Laura
论文数: 0引用数: 0
h-index: 0
机构:
VHIO, Cellex Ctr, Barcelona 08035, Spain
ICREA, Barcelona 08010, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Bellaterra 08193, SpainUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Soucek, Laura
;
Venkataraman, Sujatha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn Pediat Brain Tumor Res Program, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Venkataraman, Sujatha
;
Vibhakar, Rajeev
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn Pediat Brain Tumor Res Program, Aurora, CO 80045 USA
Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
Ayyanar, Pavithra
;
Mishra, Pritinanda
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
Mishra, Pritinanda
;
Preetam, Chappity
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept ENT, Bhubaneswar, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
Preetam, Chappity
;
Adhya, Amit Kumar
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
机构:
Department of Pathology, The Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MD
Department of Otolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MDDepartment of Pathology, The Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MD
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Alimova, Irina
;
Pierce, Angela
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Pierce, Angela
;
Danis, Etienne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Danis, Etienne
;
Donson, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Donson, Andrew
;
Birks, Diane K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Birks, Diane K.
;
Griesinger, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Griesinger, Andrea
;
Foreman, Nicholas K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn Pediat Brain Tumor Res Program, Aurora, CO 80045 USA
Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Foreman, Nicholas K.
;
Santi, Mariarita
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Univ Penn Perelman, Sch Med, Philadelphia, PA 19104 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Santi, Mariarita
;
Soucek, Laura
论文数: 0引用数: 0
h-index: 0
机构:
VHIO, Cellex Ctr, Barcelona 08035, Spain
ICREA, Barcelona 08010, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Bellaterra 08193, SpainUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Soucek, Laura
;
Venkataraman, Sujatha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn Pediat Brain Tumor Res Program, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Venkataraman, Sujatha
;
Vibhakar, Rajeev
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
Childrens Hosp Colorado, Morgan Adams Fdn Pediat Brain Tumor Res Program, Aurora, CO 80045 USA
Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
Ayyanar, Pavithra
;
Mishra, Pritinanda
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
Mishra, Pritinanda
;
Preetam, Chappity
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept ENT, Bhubaneswar, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
Preetam, Chappity
;
Adhya, Amit Kumar
论文数: 0引用数: 0
h-index: 0
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bhubaneswar 751019, Odisha, India
机构:
Department of Pathology, The Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MD
Department of Otolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MDDepartment of Pathology, The Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg 2249, Baltimore, 21231, MD