Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis

被引：5
作者：
von Eyben, Finn E. [1 ]
Kristiansen, Karsten [2 ,3 ,4 ]
Kapp, Daniel S. [5 ]
Hu, Rong [6 ]
Preda, Ovidiu [7 ]
Nogales, Francisco F. [8 ]
机构：
[1] Ctr Tobacco Control Res, Birkevej 17, DK-5230 Odense, Denmark
[2] Univ Copenhagen, August Krogh Bldg Dept Biol, Lab Genom & Mol Biomed, Univ Pk 13, DK-2100 Copenhagen, Denmark
[3] BGI Shenzhen, BGI Res, Shenzhen 518120, Peoples R China
[4] BGI Qingdao, Inst Metagen, Qingdao Europe Adv Inst Life Sci, Qingdao 166555, Peoples R China
[5] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA
[6] Univ Wisconsin Hosp & Clin, Dept Pathol, Lab Med, Madison, WI 53792 USA
[7] San Cecilio Univ Hosp, Dept Pathol, Granada 18071, CP, Spain
[8] Univ Granada, Sch Med, Dept Pathol, Granada 18071, CP, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
关键词：
differentiation; epigenetics; LIN28; NANOG; SOX2; testis cancer; GERM-CELL TUMORS; EMBRYONIC STEM-CELLS; LACTATE-DEHYDROGENASE ISOENZYME-1; COMPARATIVE GENOMIC HYBRIDIZATION; DNA METHYLATION; IN-SITU; DIFFERENTIAL EXPRESSION; CISPLATIN RESISTANCE; PROMOTER METHYLATION; CHROMOSOMAL CHANGES;
D O I：
10.3390/ijms24044148
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17, KLF4, and MYC, and embryonal carcinoma (EC) has four upregulated genes, OCT4/POU5F1, SOX2, LIN28, and NANOG. The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation of the driver genes are important for TGCT and for oncology in general.
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页数：28
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