T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

被引：29

作者：

Chi, Xiaoxia ^{[1
,2
]}

Luo, Shahang ^{[1
,2
]}

Ye, Peng ^{[3
]}

Hwang, Wei-Lun ^{[4
,5
]}

Cha, Jong-Ho ^{[6
,7
]}

Yan, Xiuwen ^{[1
,2
]}

Yang, Wen-Hao ^{[8
]}

机构：

[1] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Guangdong Higher Educ Inst, Key Lab Cell Homeostasis & Canc Res, Guangzhou, Guangdong, Peoples R China

[3] Guangzhou Panyu Cent Hosp, Dept Infect Dis, Guangzhou, Guangdong, Peoples R China

[4] Natl Yang Ming Chiao Tung Univ, Dept Biotechnol & Lab Sci Med, Taipei, Taiwan

[5] Natl Yang Ming Chiao Tung Univ, Canc Progress Res Ctr, Taipei, Taiwan

[6] Inha Univ, Coll Med, Dept Biomed Sci, Incheon, South Korea

[7] Inha Univ, Program Biomed Sci & Engn, Incheon, South Korea

[8] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

exhaustion; stemness; T-SCM; chronic antigenic stimulation; cancer immunotherapy; B-CELL; ADOPTIVE IMMUNOTHERAPY; TUMOR MICROENVIRONMENT; PD-1; BLOCKADE; IN-VIVO; MEMORY; EFFECTOR; DIFFERENTIATION; CANCER; PERSISTENCE;

D O I：

10.3389/fimmu.2023.1104771

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells play a crucial role in the regulation of immune response and are integral to the efficacy of cancer immunotherapy. Because immunotherapy has emerged as a promising treatment for cancer, increasing attention has been focused on the differentiation and function of T cells in immune response. In this review, we describe the research progress on T-cell exhaustion and stemness in the field of cancer immunotherapy and summarize advances in potential strategies to intervene and treat chronic infection and cancer by reversing T-cell exhaustion and maintaining and increasing T-cell stemness. Moreover, we discuss therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and promote continuous breakthroughs in the anticancer activity of T cells.

引用

页数：18

共 216 条

[1]

Abrams D, 2009, NEW ENGL J MED, V361, P1548, DOI 10.1056/NEJMoa0903175

[2] Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes [J].

Adams, Sarah F. ;

Grimm, Alizee J. ;

Chiang, Cheryl L-L ;

Mookerjee, Ananda ;

Flies, Dallas ;

Jean, Stephanie ;

McCann, Georgia A. ;

Michaux, Justine ;

Pak, HuiSong ;

Huber, Florian ;

Neal, Christopher ;

Dangaj, Denarda ;

Bassani-Sternberg, Michal ;

Rusakiewicz, Sylvie ;

Facciabene, Andrea ;

Coukos, George ;

Gimotty, Phyllis A. ;

Kandalaft, Lana E. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)

[3] Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux [J].

Ahmed, Raya ;

Roger, Laureline ;

del Amo, Pedro Costa ;

Miners, Kelly L. ;

Jones, Rhiannon E. ;

Boelen, Lies ;

Fali, Tinhinane ;

Elemans, Marjet ;

Zhang, Yan ;

Appay, Victor ;

Baird, Duncan M. ;

Asquith, Becca ;

Price, David A. ;

Macallan, Derek C. ;

Ladell, Kristin .

CELL REPORTS, 2016, 17 (11) :2811-2818

[4] TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection [J].

Alfei, Francesca ;

Kanev, Kristiyan ;

Hofmann, Maike ;

Wu, Ming ;

Ghoneim, Hazem E. ;

Roelli, Patrick ;

Utzschneider, Daniel T. ;

von Hoesslin, Madlaina ;

Cullen, Jolie G. ;

Fan, Yiping ;

Eisenberg, Vasyl ;

Wohlleber, Dirk ;

Steiger, Katja ;

Merkler, Doron ;

Delorenzi, Mauro ;

Knolle, Percy A. ;

Cohen, Cyrille J. ;

Thimme, Robert ;

Youngblood, Benjamin ;

Zehn, Dietmar .

NATURE, 2019, 571 (7764) :265-+

[5] Next-Generation Manufacturing Protocols Enriching TSCMCAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients [J].

Arcangeli, Silvia ;

Falcone, Laura ;

Camisa, Barbara ;

De Girardi, Federica ;

Biondi, Marta ;

Giglio, Fabio ;

Ciceri, Fabio ;

Bonini, Chiara ;

Bondanza, Attilio ;

Casucci, Monica .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[6] Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells [J].

Baharom, Faezzah ;

Ramirez-Valdez, Ramiro A. ;

Tobin, Kennedy K. S. ;

Yamane, Hidehiro ;

Dutertre, Charles-Antoine ;

Khalilnezhad, Ahad ;

Reynoso, Glennys, V ;

Coble, Vincent L. ;

Lynn, Geoffrey M. ;

Mule, Matthew P. ;

Martins, Andrew J. ;

Finnigan, John P. ;

Zhang, Xiao Meng ;

Hamerman, Jessica A. ;

Bhardwaj, Nina ;

Tsang, John S. ;

Hickman, Heather D. ;

Ginhoux, Florent ;

Ishizuka, Andrew S. ;

Seder, Robert A. .

NATURE IMMUNOLOGY, 2021, 22 (01) :41-52

[7] T cell exhaustion and Interleukin 2 downregulation [J].

Balkhi, Mumtaz Y. ;

Ma, Qiangzhong ;

Ahmad, Shazia ;

Junghans, Richard P. .

CYTOKINE, 2015, 71 (02) :339-347

[8] Pathways of memory CD8+ T-cell development [J].

Bannard, Oliver ;

Kraman, Matthew ;

Fearon, Douglas .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (08) :2083-2087

[9] Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion [J].

Bengsch, Bertram ;

Johnson, Andy L. ;

Kurachi, Makoto ;

Odorizzi, Pamela M. ;

Pauken, Kristen E. ;

Attanasio, John ;

Stelekati, Erietta ;

McLane, Laura M. ;

Paley, Michael A. ;

Delgoffe, Greg M. ;

Wherry, E. John .

IMMUNITY, 2016, 45 (02) :358-373

[10] Restoration of HBV-specific CD8+T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation [J].

Bengsch, Bertram ;

Martin, Bianca ;

Thimme, Robert .

JOURNAL OF HEPATOLOGY, 2014, 61 (06) :1212-1219

← 1 2 3 4 5 6 7 8 9 10 →