Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19

被引：3
作者：
Kirk, Natalie M. [1 ]
Liang, Yuying [1 ]
Ly, Hinh [1 ]
机构：
[1] Univ Minnesota, Coll Vet Med, Dept Vet & Biomed Sci, Minneapolis, MN 55455 USA
来源：
VIRULENCE | 2024年 / 15卷 / 01期
关键词：
Respiratory pathogens; coronaviruses; animal models; pathology; pathogenesis; ACUTE RESPIRATORY SYNDROME; DIPEPTIDYL PEPTIDASE 4; SARS-CORONAVIRUS; FUNCTIONAL RECEPTOR; AMINOPEPTIDASE-N; INFECTION; SARS-COV-2; MICE; PROTEIN; MERS;
D O I：
10.1080/21505594.2024.2316438
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.
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页数：22
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