Age-dependent cognitive decline is associated with a downregulation of the cyclic nucleotide cascade. Through their regulation of the cGMP pathway, phosphodiesterase 5 inhibitors have been proven to enhance episodic memory in rodents and mice and have been proposed as drugs with the potential to counteract aging-dependent cognitive and neurodegenerative disorders. One caveat of this line of research is that these studies have been carried out in male rodents, leaving unknown their effects on female cognition. With the present study, we aim to fill this methodological gap. Twenty-four-month-old female mice were exposed to a continuous 33-day treatment with 2 mg/kg of Vardenafil and tested in the object recognition test, the elevated plus maze, and the open field test. The results show that, compared to females from the control group, Vardenafil-exposed females showed higher discrimination between familiar and novel objects compared to controls both at 1 h and 24 h delays, indicating that Vardenafil enhances episodic memory. No effects of Vardenafil on anxiety-like behaviors were found.
机构:
IFR 146 ICORE, EA3915, GMPc, F-14000 Caen, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Bouet, Valentine
Freret, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
IFR 146 ICORE, EA3915, GMPc, F-14000 Caen, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Freret, Thomas
Dutar, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Dutar, Patrick
Billard, Jean-Marie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Billard, Jean-Marie
Boulouard, Michel
论文数: 0引用数: 0
h-index: 0
机构:
IFR 146 ICORE, EA3915, GMPc, F-14000 Caen, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
机构:
Univ Melbourne, Florey Inst, Melbourne, Vic, Australia
Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic, Australia
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Buckley, Rachel F.
Mormino, Elizabeth C.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Neurol, Stanford, CA 94305 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Mormino, Elizabeth C.
Amariglio, Rebecca E.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Amariglio, Rebecca E.
Properzi, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Properzi, Michael J.
Rabin, Jennifer S.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston, MA 02115 USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Papp, Kathryn V.
Jacobs, Heidi I. L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USA
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, Maastricht, NetherlandsUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Jacobs, Heidi I. L.
Burnham, Samantha
论文数: 0引用数: 0
h-index: 0
机构:
CSIRO Hlth Biosecur, Australian eHlth Res Ctr, Parkville, Vic, AustraliaUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Burnham, Samantha
Hanseeuw, Bernard J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USA
Catholic Univ Louvain, Inst Neurosci, Clin Univ St Luc, Dept Neurol, Brussels, BelgiumUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Hanseeuw, Bernard J.
Dore, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
CSIRO Hlth Biosecur, Australian eHlth Res Ctr, Brisbane, Qld, AustraliaUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Univ Southern Calif, Dept Neurol, San Diego, CA USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Donohue, Michael C.
Rentz, Dorene M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Rentz, Dorene M.
Kirn, Dylan
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Kirn, Dylan
Hedden, Trey
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Hedden, Trey
Chhatwal, Jasmeer
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Chhatwal, Jasmeer
Schultz, Aaron P.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Schultz, Aaron P.
Johnson, Keith A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Dept Psychol, Boca Raton, FL 33431 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Cinalli Jr., David A.
Cohen, Sarah J.
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Cohen, Sarah J.
Guthrie, Kathleen
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Biomed Sci, Boca Raton, FL 33431 USA
Florida Atlantic Univ, FAU Brain Inst, Jupiter, FL 33458 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Guthrie, Kathleen
Stackman Jr., Robert W.
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Dept Psychol, Boca Raton, FL 33431 USA
Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USA
Florida Atlantic Univ, FAU Brain Inst, Jupiter, FL 33458 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Stackman Jr., Robert W.
[J].
FRONTIERS IN MOLECULAR NEUROSCIENCE,
2020,
13
机构:
IFR 146 ICORE, EA3915, GMPc, F-14000 Caen, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Bouet, Valentine
Freret, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
IFR 146 ICORE, EA3915, GMPc, F-14000 Caen, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Freret, Thomas
Dutar, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Dutar, Patrick
Billard, Jean-Marie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
Billard, Jean-Marie
Boulouard, Michel
论文数: 0引用数: 0
h-index: 0
机构:
IFR 146 ICORE, EA3915, GMPc, F-14000 Caen, FranceUniv Paris 05, Fac Med Rene Descartes, Ctr Psychiat & Neurosci, UMR 894, F-75014 Paris, France
机构:
Univ Melbourne, Florey Inst, Melbourne, Vic, Australia
Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic, Australia
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Buckley, Rachel F.
Mormino, Elizabeth C.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Neurol, Stanford, CA 94305 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Mormino, Elizabeth C.
Amariglio, Rebecca E.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Amariglio, Rebecca E.
Properzi, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Properzi, Michael J.
Rabin, Jennifer S.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston, MA 02115 USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Papp, Kathryn V.
Jacobs, Heidi I. L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USA
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Fac Hlth Med & Life Sci, Maastricht, NetherlandsUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Jacobs, Heidi I. L.
Burnham, Samantha
论文数: 0引用数: 0
h-index: 0
机构:
CSIRO Hlth Biosecur, Australian eHlth Res Ctr, Parkville, Vic, AustraliaUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Burnham, Samantha
Hanseeuw, Bernard J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USA
Catholic Univ Louvain, Inst Neurosci, Clin Univ St Luc, Dept Neurol, Brussels, BelgiumUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Hanseeuw, Bernard J.
Dore, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
CSIRO Hlth Biosecur, Australian eHlth Res Ctr, Brisbane, Qld, AustraliaUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Univ Southern Calif, Dept Neurol, San Diego, CA USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Donohue, Michael C.
Rentz, Dorene M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Rentz, Dorene M.
Kirn, Dylan
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Kirn, Dylan
Hedden, Trey
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Hedden, Trey
Chhatwal, Jasmeer
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Chhatwal, Jasmeer
Schultz, Aaron P.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
Schultz, Aaron P.
Johnson, Keith A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Massachusetts Gen Hosp, Dept Neurol, Harvard Aging Brain Study, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA 02115 USA
Brigham & Womens Hosp, Ctr Alzheimer Res & Treatment, Dept Neurol, 75 Francis St, Boston, MA 02115 USAUniv Melbourne, Florey Inst, Melbourne, Vic, Australia
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Dept Psychol, Boca Raton, FL 33431 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Cinalli Jr., David A.
Cohen, Sarah J.
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Cohen, Sarah J.
Guthrie, Kathleen
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Biomed Sci, Boca Raton, FL 33431 USA
Florida Atlantic Univ, FAU Brain Inst, Jupiter, FL 33458 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Guthrie, Kathleen
Stackman Jr., Robert W.
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Florida Atlantic Univ, Charles E Schmidt Coll Sci, Dept Psychol, Boca Raton, FL 33431 USA
Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USA
Florida Atlantic Univ, FAU Brain Inst, Jupiter, FL 33458 USAFlorida Atlantic Univ, Charles E Schmidt Coll Sci, Jupiter Life Sci Initiat, Jupiter, FL 33458 USA
Stackman Jr., Robert W.
[J].
FRONTIERS IN MOLECULAR NEUROSCIENCE,
2020,
13