Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice

被引:0
作者
Dadomo, Harold [1 ]
Ponzi, Davide [1 ]
Paterlini, Silvia [1 ]
Parmigiani, Stefano [2 ]
Palanza, Paola [1 ]
机构
[1] Univ Parma, Dept Med & Surg, I-43121 Parma, Italy
[2] Univ Parma, Dept Chem Life Sci & Environm Sustainabil, I-43121 Parma, Italy
来源
APPLIED SCIENCES-BASEL | 2023年 / 13卷 / 22期
关键词
aging; object recognition test; sex differences; Vardenafil; OBJECT RECOGNITION MEMORY; NITRIC-OXIDE; ALZHEIMERS-DISEASE; PHOSPHODIESTERASE INHIBITORS; SYNAPTIC PLASTICITY; SILDENAFIL; AGE; BEHAVIOR; LTP; CONSOLIDATION;
D O I
10.3390/app132212470
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Age-dependent cognitive decline is associated with a downregulation of the cyclic nucleotide cascade. Through their regulation of the cGMP pathway, phosphodiesterase 5 inhibitors have been proven to enhance episodic memory in rodents and mice and have been proposed as drugs with the potential to counteract aging-dependent cognitive and neurodegenerative disorders. One caveat of this line of research is that these studies have been carried out in male rodents, leaving unknown their effects on female cognition. With the present study, we aim to fill this methodological gap. Twenty-four-month-old female mice were exposed to a continuous 33-day treatment with 2 mg/kg of Vardenafil and tested in the object recognition test, the elevated plus maze, and the open field test. The results show that, compared to females from the control group, Vardenafil-exposed females showed higher discrimination between familiar and novel objects compared to controls both at 1 h and 24 h delays, indicating that Vardenafil enhances episodic memory. No effects of Vardenafil on anxiety-like behaviors were found.
引用
收藏
页数:10
相关论文
共 51 条
  • [1] Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice
    Al-Amin, Md. Mamun
    Hasan, S. M. Nageeb
    Alam, Tanzir
    Hasan, Ahmed Tasdid
    Hossain, Imran
    Didar, Rohini Rowshan
    Alam, Md. Ashraful
    Rahman, Md. Mahbubur
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 745 : 84 - 90
  • [2] Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot
    Argyrousi, Elentina K.
    Heckman, Pim R. A.
    Prickaerts, Jos
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2020, 113 : 12 - 38
  • [3] Bartolomucci A, 2009, NEUROMETHODS, V42, P261, DOI 10.1007/978-1-60761-303-9_14
  • [4] The role of environmental familiarization in novel-object preference
    Besheer, J
    Bevins, RA
    [J]. BEHAVIOURAL PROCESSES, 2000, 50 (01) : 19 - 29
  • [5] Improved Long-Term Memory via Enhancing cGMP-PKG Signaling Requires cAMP-PKA Signaling
    Bollen, Eva
    Puzzo, Daniela
    Rutten, Kris
    Privitera, Lucia
    De Vry, Jochen
    Vanmierlo, Tim
    Kenis, Gunter
    Palmeri, Agostino
    D'Hooge, Rudi
    Balschun, Detlef
    Steinbusch, Harry M. W.
    Blokland, Arjan
    Prickaerts, Jos
    [J]. NEUROPSYCHOPHARMACOLOGY, 2014, 39 (11) : 2497 - 2505
  • [6] Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals
    Bouet, Valentine
    Freret, Thomas
    Dutar, Patrick
    Billard, Jean-Marie
    Boulouard, Michel
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2011, 132 (05) : 240 - 248
  • [7] Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts
    Buckley, Rachel F.
    Mormino, Elizabeth C.
    Amariglio, Rebecca E.
    Properzi, Michael J.
    Rabin, Jennifer S.
    Lim, Yen Ying
    Papp, Kathryn V.
    Jacobs, Heidi I. L.
    Burnham, Samantha
    Hanseeuw, Bernard J.
    Dore, Vincent
    Dobson, Annette
    Masters, Colin L.
    Waller, Michael
    Rowe, Christopher C.
    Maruff, Paul
    Donohue, Michael C.
    Rentz, Dorene M.
    Kirn, Dylan
    Hedden, Trey
    Chhatwal, Jasmeer
    Schultz, Aaron P.
    Johnson, Keith A.
    Villemagne, Victor L.
    Sperling, Reisa A.
    [J]. ALZHEIMERS & DEMENTIA, 2018, 14 (09) : 1193 - 1203
  • [8] Object Recognition Memory: Distinct Yet Complementary Roles of the Mouse CA1 and Perirhinal Cortex
    Cinalli Jr., David A.
    Cohen, Sarah J.
    Guthrie, Kathleen
    Stackman Jr., Robert W.
    [J]. FRONTIERS IN MOLECULAR NEUROSCIENCE, 2020, 13
  • [9] The interactive effect of acute ovarian suppression and the cholinergic system on visuospatial working memory in young women
    Craig, M. C.
    Brammer, M.
    Maki, P. M.
    Fletcher, P. C.
    Daly, E. M.
    Rymer, J.
    Giampietro, V.
    Picchioni, M.
    Stahl, D.
    Murphy, Declan G. M.
    [J]. PSYCHONEUROENDOCRINOLOGY, 2010, 35 (07) : 987 - 1000
  • [10] Repeated and chronic administration of Vardenafil or Sildenafil differentially affects emotional and socio-sexual behavior in mice
    Dadomo, H.
    Parmigiani, S.
    Nicolini, Y.
    Freschini, S.
    Gioiosa, L.
    Patrelli, T. S.
    Palanza, P.
    Volpi, R.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2013, 253 : 103 - 112