The role of angiogenic growth factors in the immune microenvironment of glioma

被引：9
作者：
Ge, Zhengmao [1 ]
Zhang, Qi [1 ]
Lin, Wei [1 ]
Jiang, Xiaofan [1 ]
Zhang, Yanyu [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
基金：
中国国家自然科学基金;
关键词：
angiogenic growth factor; immune cell; glioma; immune modulation; tumor microenvironment; TUMOR-ASSOCIATED MACROPHAGES; RECEPTOR TYROSINE KINASES; CD8(+) T-CELLS; DENDRITIC CELLS; LYMPHOCYTE INFILTRATION; DIFFERENTIAL EXPRESSION; FACTOR-BETA; STEM-CELLS; PDGFR-BETA; GLIOBLASTOMA;
D O I：
10.3389/fonc.2023.1254694
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Angiogenic growth factors (AGFs) are a class of secreted cytokines related to angiogenesis that mainly include vascular endothelial growth factors (VEGFs), stromal-derived factor-1 (SDF-1), platelet-derived growth factors (PDGFs), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-& beta;) and angiopoietins (ANGs). Accumulating evidence indicates that the role of AGFs is not only limited to tumor angiogenesis but also participating in tumor progression by other mechanisms that go beyond their angiogenic role. AGFs were shown to be upregulated in the glioma microenvironment characterized by extensive angiogenesis and high immunosuppression. AGFs produced by tumor and stromal cells can exert an immunomodulatory role in the glioma microenvironment by interacting with immune cells. This review aims to sum up the interactions among AGFs, immune cells and cancer cells with a particular emphasis on glioma and tries to provide new perspectives for understanding the glioma immune microenvironment and in-depth explorations for anti-glioma therapy.
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页数：13
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