Advances in nanomaterial-based targeted drug delivery systems

被引：117

作者：

Cheng, Xiaoxiao ^{[1
]}

Xie, Qirong ^{[1
]}

Sun, Yang ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Ultrasound,Chongqing Key Lab Ultrasound Mol I, Chongqing, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2023年 / 11卷

关键词：

nanomaterials; nano-drug delivery system; surface modification; targeted delivery; EPR; blood brain barrier; MEMBRANE-COATED NANOPARTICLES; ULTRASOUND-MEDIATED DELIVERY; INTENSITY FOCUSED ULTRASOUND; TUMOR-ASSOCIATED MACROPHAGES; INTERSTITIAL FLUID PRESSURE; SOLID LIPID NANOPARTICLES; BLOOD-BRAIN-BARRIER; EXTRACELLULAR VESICLES; IN-VIVO; POLYMERIC NANOPARTICLES;

D O I：

10.3389/fbioe.2023.1177151

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases.

引用

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