Anti-aging effect of methylurolithin A and its amide derivatives on nematode Caenorhabditis elegans

被引：3

作者：

Tang, Long ^{[1
,2
]}

Chen, Xi ^{[1
,2
]}

Kong, Xiang-ming ^{[3
]}

Liu, Tian -wen ^{[1
,2
]}

Feng, Xiao-qing ^{[1
,2
]}

Chen, Fen-er ^{[1
,2
,4
]}

Zhuang, Zi-heng ^{[1
,2
,5
]}

机构：

[1] Changzhou Univ, Sch Pharm, Changzhou 213164, Peoples R China

[2] Changzhou Univ, Sch Biol & Food Engn, Changzhou 213164, Peoples R China

[3] Changzhou Railway Higher Vocat & Tech Sch, Changzhou 213011, Peoples R China

[4] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[5] Changzhou Tradit Chinese Med Hosp, Changzhou 213004, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 118卷

关键词：

Methylurolithin A; Amide derivatives; Anti-aging; Caenorhabditis elegans; Biosafety; LIFE-SPAN; UROLITHIN; DISEASE;

D O I：

10.1016/j.tetlet.2023.154389

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

At present, the global irreversible rapid population aging will cause serious social healthcare burden and economic downward pressure for many countries or regions. Urolithin A (UA) has received extensive attention and research due to its role in inducing mitophagy and improving muscle capacity. Methylurolithin A (mUA) and its nine amide derivatives were synthesized in this study in order to find potential drugs with better anti-aging effects. The anti-aging and biosafety of the synthesized compounds were evaluated using Caenorhabditis elegans (C. elegans). The results showed that among mUA and its nine amide derivatives, Cpd. 6 had the best anti-aging effect, and had good biosafety in the growth, reproduction and motility of C. elegans. Therefore, we believe that Cpd. 6 is most suitable to be considered as a potential anti-aging drug for further development and investigation. (c) 2023 Published by Elsevier Ltd.

引用

页数：6

共 31 条

[31] A natural product solution to aging and aging-associated diseases [J].

Yang, Chuanbin ;

Zhang, Wei ;

Dong, Xiaoduo ;

Fu, Chunjin ;

Yuan, Jimin ;

Xu, Menglong ;

Liang, Zhen ;

Qiu, Chen ;

Xu, Chengchao .

PHARMACOLOGY & THERAPEUTICS, 2020, 216

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