Anti-aging effect of methylurolithin A and its amide derivatives on nematode Caenorhabditis elegans

被引：2
作者：
Tang, Long [1 ,2 ]
Chen, Xi [1 ,2 ]
Kong, Xiang-ming [3 ]
Liu, Tian -wen [1 ,2 ]
Feng, Xiao-qing [1 ,2 ]
Chen, Fen-er [1 ,2 ,4 ]
Zhuang, Zi-heng [1 ,2 ,5 ]
机构：
[1] Changzhou Univ, Sch Pharm, Changzhou 213164, Peoples R China
[2] Changzhou Univ, Sch Biol & Food Engn, Changzhou 213164, Peoples R China
[3] Changzhou Railway Higher Vocat & Tech Sch, Changzhou 213011, Peoples R China
[4] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[5] Changzhou Tradit Chinese Med Hosp, Changzhou 213004, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 118卷
关键词：
Methylurolithin A; Amide derivatives; Anti-aging; Caenorhabditis elegans; Biosafety; LIFE-SPAN; UROLITHIN; DISEASE;
D O I：
10.1016/j.tetlet.2023.154389
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
At present, the global irreversible rapid population aging will cause serious social healthcare burden and economic downward pressure for many countries or regions. Urolithin A (UA) has received extensive attention and research due to its role in inducing mitophagy and improving muscle capacity. Methylurolithin A (mUA) and its nine amide derivatives were synthesized in this study in order to find potential drugs with better anti-aging effects. The anti-aging and biosafety of the synthesized compounds were evaluated using Caenorhabditis elegans (C. elegans). The results showed that among mUA and its nine amide derivatives, Cpd. 6 had the best anti-aging effect, and had good biosafety in the growth, reproduction and motility of C. elegans. Therefore, we believe that Cpd. 6 is most suitable to be considered as a potential anti-aging drug for further development and investigation. (c) 2023 Published by Elsevier Ltd.
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