Electrochemical Reactors Enable Divergent Site Selectivity in the C-H Carboxylation of N-Heteroarenes

被引：9

作者：

Wang, Peng-Zi ^{[1
]}

Xiao, Wen-Jing ^{[1
,2
]}

Chen, Jia-Rong ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China

[2] Wuhan Inst Photochem & Technol, 7 North Bingang Rd, Wuhan 430082, Hubei, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 21期

关键词：

C-H Carboxylation; Curtin-Hammett Principle; Electrochemistry; Radical Anion; SET-Reduction; FUNCTIONALIZATION;

D O I：

10.1002/anie.202302227

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic and switchable C-H functionalization of N-heteroarenes under easily tunable conditions is a robust but challenging tool for the construction of biologically relevant compounds. Recently, a general electrochemical strategy has been developed for the direct C-H carboxylation of N-heteroarenes with CO2, and by simply choosing different types of cell setups, carboxylated products are furnished with excellent and tunable site selectivity. This study also paves the way for regulating the reactivity modes in electrochemical synthesis.

引用

页数：3

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