Recent progress in the genetic and epigenetic underpinnings of atopy

被引：20

作者：

Baloh, Carolyn H. ^{[1
,2
]}

Mathias, Rasika A. ^{[3
,4
]}

机构：

[1] Immune Tolerance Network, Benaroya Res Inst Virginia Mason, Seattle, WA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Al lergy & Clin Immunol, Boston, MA USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Div Allergy & Clin Immunol, Baltimore, MD USA

[4] 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 151卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Genetics; polygenic risk score; family history; genome-wide association; methylation; atopy; atopic march; asthma; food al-lergy; atopic dermatitis; DNA METHYLATION; NASAL TRANSCRIPTOME; GENOME-WIDE; ASTHMA; ASSOCIATION; DERMATITIS; SEVERITY; FAMILY; LANDSCAPE; VARIANTS;

D O I：

10.1016/j.jaci.2022.10.027

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In the past 2 years, there continue to be advances in our understanding of the genetic and epigenetic underpinnings of atopy pertaining to disease risk and disease severity. The joint role of genetics and the environment has been emphasized in multiple studies. Combining genetics with family history, biomarkers, and comorbidities is further refining our ability to predict the development of individual atopic diseases as well as the advancement of the atopic march. Polygenic risk scores will be an important next step for the field moving toward clinical translation of the genetic findings thus far. A systems biology approach, as illustrated by studies of the microbiome and epigenome, will be necessary to fully understand disease development and to develop increasingly targeted therapeutics. (J Allergy Clin Immunol 2023;151:60-9.)

引用

页码：60 / 69

页数：10

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