Pridopidine exerts neuroprotective effects via activation of the Sigma-1 receptor (S1R)

被引：0

作者：

Hand, Randal ^{[1
]}

Ankol, Lior ^{[2
]}

Ionescu, Ariel ^{[2
]}

Gradus-Pery, Tal ^{[2
]}

Wang, Shao-Ming ^{[3
,4
]}

Gershoni-Emek, Noga ^{[1
]}

Su, Tsung-Ping ^{[5
]}

Perlson, Eran ^{[2
]}

Geva, Michal ^{[1
]}

Goldberg, Y. Paul ^{[1
]}

Hayden, Michael R. ^{[6
,7
]}

机构：

[1] Prilenia Therapeut BV, Naarden, Netherlands

[2] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel

[3] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[4] China Med Univ, Neurosci & Brain Dis Ctr, Taichung, Taiwan

[5] Natl Inst Drug Abuse, Cellular Pathobiol Sect, Integrat Neurosci Res Branch, Natl Inst Hlth, Baltimore, MD USA

[6] Prilenia Therapeut BV, Tel Aviv, Israel

[7] Univ British Columbia, CMMT, Vancouver, BC, Canada

来源：

MUSCLE & NERVE | 2023年 / 68卷

关键词：

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：S6 / S7

页数：2

共 50 条

[41] Multiple Brain Effects of Pridopidine in Huntington Disease Patients and Healthy Volunteers - A Simultaneous Sigma-1 Receptor PET/MRI Study [J].

Barthel, Henryk ;

Meyer, Philipp ;

Rullmann, Michael ;

Becker, Georg ;

Bronzel, Marcus ;

Marsteller, Doug ;

Zientek, Franziska ;

Sattler, Bernhard ;

Patt, Marianne ;

Kluge, Andreas ;

Savola, Juha ;

Gordon, Mark ;

Geva, Michal ;

Hesse, Swen ;

Hayden, Michael ;

Grachev, Igor ;

Sabri, Osama .

JOURNAL OF NUCLEAR MEDICINE, 2020, 61

[42] Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor [J].

Shenkman, Marina ;

Geva, Michal ;

Gershoni-Emek, Noga ;

Hayden, Michael R. ;

Lederkremer, Gerardo Z. .

JOURNAL OF NEUROCHEMISTRY, 2021, 158 (02) :467-481

[43] PRIDOPIDINE RESTORES MITOCHONDRIAL FUNCTION AND DECREASES ER STRESS WHICH IS MEDIATED THROUGH THE S1R [J].

Geva, Michal ;

Shenkman, Marina ;

Naia, Luana ;

Emek, Noga Gershoni ;

Ly, Philip ;

Mota, Sandra I. ;

Lopes, Carla ;

Ankarcrona, Maria ;

Rego, A. Cristina ;

Lederkreme, Gerardo Z. ;

Hayden, Michael R. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2021, 92 :A52-A53

[44] Activation of astrocytic sigma-1 receptor exerts antidepressant-like effect via facilitating CD38-driven mitochondria transfer [J].

Wang, Yun ;

Ni, Jing ;

Gao, Tianyu ;

Gao, Ce ;

Guo, Lin ;

Yin, Xiaoxing .

GLIA, 2020, 68 (11) :2415-2426

[45] [18F]Fluspidine and [18F]Fallypride PET study to evaluate sigma-1 receptor (S1R) and dopamine 2 / dopamine 3 receptor (D2/3R) occupancy by pridopidine in healthy volunteers (HV) and patients with Huntington disease (HD) [J].

Meyer, P. ;

Grachev, I. D. ;

Becker, G. ;

Bronzel, M. ;

Marsteller, D. ;

Pastino, G. ;

Voges, O. ;

Rabinovich, L. ;

Knebel, H. ;

Zientek, F. ;

Rullmann, M. ;

Sattler, B. ;

Patt, M. ;

Strauss, E. ;

Kluge, A. ;

Savola, J. ;

Gordon, M. F. ;

Geva, M. ;

Hesse, S. ;

Barthel, H. ;

Hayden, M. R. ;

Sabri, O. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (SUPPL 1) :S97-S97

[46] Sigma-1 and dopamine D2 receptor occupancy of the dopamine stabilizer pridopidine in the brain of living rats [J].

Sahlholm, K. ;

Sijbesma, J. W. A. ;

Maas, B. ;

Kwizera, C. ;

Ramakrishnan, N. K. ;

Dierckx, R. A. J. O. ;

Elsinga, P. H. ;

Van Waarde, A. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 :S20-S20

[47] Targeting the sigma-1 receptor with pridopidine induces functional neurorestoration in spinal cord ischemia-reperfusion injury [J].

Sweed, Eman ;

Khodir, Suzan A. ;

Motawea, Shaimaa Mohamed ;

El-Haron, Hala ;

Mostafa, Basma Abdelnaby ;

Elkholy, Mona S. ;

Salim, Mohammud ;

Shebl, Doaa Z. M. .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2025, 398 (07) :9307-9321

[48] The molecular function of the sigma-1 receptor [J].

Hayashi, Teruo .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 121 :33P-33P

[49] Simultaneous Sigma-1 Receptor PET/Multimodality MRI of the Effect of Pridopidine in Huntington Disease Patients and Healthy Volunteers [J].

Barthel, H. ;

Meyer, P. M. ;

Rullmann, M. ;

Becker, G. ;

Bronzel, M. ;

Marsteller, D. ;

Pastino, G. ;

Voges, O. ;

Rabinovich, L. ;

Knebel, H. ;

Zientek, F. ;

Sattler, B. ;

Patt, M. ;

Strauss, E. ;

Kluge, A. ;

Savola, J. ;

Gordon, M. F. ;

Geva, M. ;

Hesse, S. ;

Hayden, M. ;

Grachev, I. D. ;

Sabri, O. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (SUPPL 1) :S97-S98

[50] Sigma-1 Receptor in Motoneuron Disease [J].

Mancuso, Renzo ;

Navarro, Xavier .

SIGMA RECEPTORS: THEIR ROLE IN DISEASE AND AS THERAPEUTIC TARGETS, 2017, 964 :235-254

← 1 2 3 4 5 →