Pridopidine exerts neuroprotective effects via activation of the Sigma-1 receptor (S1R)

被引:0
|
作者
Hand, Randal [1 ]
Ankol, Lior [2 ]
Ionescu, Ariel [2 ]
Gradus-Pery, Tal [2 ]
Wang, Shao-Ming [3 ,4 ]
Gershoni-Emek, Noga [1 ]
Su, Tsung-Ping [5 ]
Perlson, Eran [2 ]
Geva, Michal [1 ]
Goldberg, Y. Paul [1 ]
Hayden, Michael R. [6 ,7 ]
机构
[1] Prilenia Therapeut BV, Naarden, Netherlands
[2] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel
[3] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
[4] China Med Univ, Neurosci & Brain Dis Ctr, Taichung, Taiwan
[5] Natl Inst Drug Abuse, Cellular Pathobiol Sect, Integrat Neurosci Res Branch, Natl Inst Hlth, Baltimore, MD USA
[6] Prilenia Therapeut BV, Tel Aviv, Israel
[7] Univ British Columbia, CMMT, Vancouver, BC, Canada
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:S6 / S7
页数:2
相关论文
共 50 条
  • [21] The Neuroprotective Effect of Activation of Sigma-1 Receptor on Neural Injury by Optic Nerve Crush
    Chen, Yao
    Yang, Xueli
    Mao, Junfeng
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2023, 64 (12)
  • [22] Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor
    Ryskamp, Daniel
    Wu, Lili
    Wu, Jun
    Kim, Dabin
    Rammes, Gerhard
    Geva, Michal
    Hayden, Michael
    Bezprozvanny, Ilya
    NEUROBIOLOGY OF DISEASE, 2019, 124 : 489 - 504
  • [23] Pridopidine Rescues Multiple Mitochondrial Functions Impaired in Human and Mouse HD Models by Activation of the Sigma-1 Receptor
    Geva, Michal
    Naia, Luana
    Ly, Philip
    Lopes, Carla
    Mota, Sandra I.
    Maranga, Carina
    Hayden, Michael
    Rego, A. Cristina
    NEUROTHERAPEUTICS, 2019, 16 (04) : 1361 - 1361
  • [24] The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models
    Naia, Luana
    Ly, Philip
    Mota, Sandra I.
    Lopes, Carla
    Maranga, Carina
    Coelho, Patricia
    Gershoni-Emek, Noga
    Ankarcrona, Maria
    Geva, Michal
    Hayden, Michael R.
    Rego, A. Cristina
    NEUROTHERAPEUTICS, 2021, 18 (02) : 1017 - 1038
  • [25] The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models
    Luana Naia
    Philip Ly
    Sandra I. Mota
    Carla Lopes
    Carina Maranga
    Patrícia Coelho
    Noga Gershoni-Emek
    Maria Ankarcrona
    Michal Geva
    Michael R. Hayden
    A. Cristina Rego
    Neurotherapeutics, 2021, 18 : 1017 - 1038
  • [26] The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism
    Liu, Xin
    Qu, Chuan
    Shi, Shaobo
    Ye, Tianxin
    Wang, Linglin
    Liu, Steven
    Zhang, Cui
    Liang, Jinjun
    Hu, Dan
    Yang, Bo
    FRONTIERS IN PHYSIOLOGY, 2019, 10
  • [27] Comments to "Fluvoxamine and long COVID-19: a new role for sigma-1 receptor (S1R) agonists" by Khani and Entezari-Maleki
    Hashimoto, Yaeko
    Suzuki, Takuji
    Hashimoto, Kenji
    MOLECULAR PSYCHIATRY, 2022, 27 (09) : 3563 - 3564
  • [28] Comments to “Fluvoxamine and long COVID-19: a new role for sigma-1 receptor (S1R) agonists” by Khani and Entezari-Maleki
    Yaeko Hashimoto
    Takuji Suzuki
    Kenji Hashimoto
    Molecular Psychiatry, 2022, 27 : 3563 - 3564
  • [29] Are fluoxetine's effects due to sigma-1 receptor agonism?
    Safrany, S. T.
    Brimson, J. M.
    PHARMACOLOGICAL RESEARCH, 2016, 113 : 707 - 708
  • [30] Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
    Ionescu, Ariel
    Gradus, Tal
    Altman, Topaz
    Maimon, Roy
    Avraham, Noi Saraf
    Geva, Michal
    Hayden, Michael
    Perlson, Eran
    CELL DEATH & DISEASE, 2019, 10 (3)