Photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access 2,4-disubstituted quinolines

被引：4

作者：

Huang, Peng-Fei ^{[1
]}

Fu, Jia-Le ^{[1
]}

Huang, Jia-Jing ^{[1
]}

Xiong, Bi-Quan ^{[1
]}

Tang, Ke-Wen ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

MULTICOMPONENT REACTIONS; BIOLOGICAL EVALUATION; LIGHT; ISONITRILES; CATALYSIS; INSERTION;

D O I：

10.1039/d3ob01915b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report an efficient photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access a wide range of 2,4-disubstituted quinolines. Preliminary mechanism experiment results suggested that this reaction was initiated by an acyl radical generated from acyl chlorides through a single-electron-transfer (SET) process. This transformation showed good substrate suitability and functional group compatibility at room temperature.

引用

页码：513 / 520

页数：8

共 11 条

[1] Photoredox Radical Cyclization of o-Vinylaryl Isocyanides and Aryldiazonium Tetrafluoroborates for the Synthesis of 2,4-Disubstituted Quinolines
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[2] Visible-light-induced synthesis of 2,4-disubstituted quinolines from o-vinylaryl isocyanides and oxime esters
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[10] One-pot synthesis of 2,4-disubstituted quinolines via three-component reaction of amines, aldehydes and alkynes using Al2O3 nanoparticles/methanesulfonic acid (nano-AMA) as a new catalyst
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