C(sp)-C(sp3) Bond Formation through Ligand- and Additive-Free CuO-Mediated Decarboxylative Direct Cross-Coupling of Coumarin-/Chromone-3-carboxylic Acids and Terminal Alkynes

被引：5
|
作者：
Bhowmick, Anindita [1 ]
Brahmachari, Goutam [1 ]
机构：
[1] Visva Bharati, Dept Chem, Lab Nat Prod & Organ Synth, Santini Ketan 731235, West Bengal, India
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 39期
关键词：
COUMARINS; FUNCTIONALIZATION; ACETYLENES; DESIGN; AGENTS;
D O I：
10.1021/acs.orglett.3c02369
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical and efficient method for the synthesis of functionalized 4-(aryl-/heteroaryl-ethynyl)chroman-2-ones and 2-(aryl-/heteroaryl-ethynyl)chroman-4-ones through copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes, leading to the formation of C(sp)-C(sp(3)) bonds, has been unearthed. Advantages of this protocol include avoidance of any ligands and bases, a broad substrate scope, tolerance of diverse functional groups, and good to excellent yields.
引用
收藏
页码：7095 / 7099
页数：5
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