Multivariate analysis of seizure outcomes after resective surgery for focal epilepsy: a single-center study on 833 patients

被引：4

作者：

Meng, Qiang ^{[1
,2
]}

Liu, Yong ^{[1
,2
]}

Ren, Yutao ^{[1
,2
,3
]}

Wu, Hao ^{[1
,2
,3
,4
]}

Zhang, Jiale ^{[1
,2
]}

Li, Huanfa ^{[1
,2
]}

Dong, Shan ^{[1
,2
]}

Jing, Jiangpeng ^{[1
,2
]}

Liu, Xiaofang ^{[1
,2
]}

Du, Changwang ^{[1
,2
]}

Zhang, Hua ^{[1
,2
,3
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neurosurg, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Clin Res Ctr Refractory Epilepsy Shaanxi Prov, Affiliated Hosp 1, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Ctr Brain Sci, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian, Shaanxi, Peoples R China

来源：

NEUROSURGICAL REVIEW | 2023年 / 46卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Focal epilepsy; Surgery; Seizure outcomes; Multivariate analysis; Predictor; TEMPORAL-LOBE EPILEPSY; ACUTE POSTOPERATIVE SEIZURES; SURGICAL-TREATMENT; PREDICTORS; CLASSIFICATION; SWEDEN;

D O I：

10.1007/s10143-023-01988-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The predictors of seizure outcomes after resective surgery for focal epilepsy, for an update on the features of good and poor outcomes, are investigated. A retrospective study of patients with focal epilepsy undergoing resective surgery from March 2011 to April 2019 was performed. There were 3 groups according to the seizure outcomes: seizure freedom, seizure improvement, and no improvement. Predictors of seizure outcomes were identified by multivariate logistic regression analysis. Of all 833 patients, 561 (67.3%) patients remained seizure-free at the last follow-up, 203 (24.4%) patients had seizure improvement, and 69 (8.3%) had no improvement. The mean follow-up duration was 5.2 years (range: 2.7 to 9.6). Predictors of better outcomes included epilepsy duration < 5 years, localized discharge, no. of antiepileptic drugs at surgery < 3, and temporal lobe resection. However, predictors of worse outcomes included intracranial hemorrhage in infancy, interictal abnormal discharge, intracranial electrode monitoring, and acute postoperative seizure. Our study suggests that resective surgery for focal epilepsy has satisfactory outcomes. Short epilepsy duration, localized discharge, and temporal lobe resection are positive predictors of seizure freedom. Patients with these predictors are intensively recommended for surgery.

引用

页数：13

共 35 条

[1] Treatment of epilepsy in light of the most recent advances [J].