Infections in DNA Repair Defects

被引：4

作者：

Demirdag, Yesim Yilmaz ^{[1
]}

Gupta, Sudhir ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Irvine, CA 92617 USA

来源：

PATHOGENS | 2023年 / 12卷 / 03期

关键词：

inborn errors of immunity; immunodeficiency; DNA repair disorders; ataxia telangiectasia; infections; Nijmegen breakage syndrome; Bloom syndrome; NIJMEGEN BREAKAGE SYNDROME; RETICULATE PIGMENTARY DISORDER; ATAXIA-TELANGIECTASIA; FACIAL DYSMORPHISM; SHORT STATURE; CLINICAL CHARACTERISTICS; SYSTEMIC MANIFESTATIONS; CENTROMERIC INSTABILITY; GROWTH-RETARDATION; BLOOMS-SYNDROME;

D O I：

10.3390/pathogens12030440

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected in a subset of these disorders leading to susceptibility to infections and autoimmunity. Infections in DNA repair defects may occur due to primary defects in T, B, or NK cells and other factors such as anatomic defects, neurologic disorders, or during chemotherapy. Consequently, the characteristics of the infections may vary from mild upper respiratory tract infections to severe, opportunistic, and even fatal infections with bacteria, viruses, or fungi. Here, infections in 15 rare and sporadic DNA repair defects that are associated with immunodeficiencies are discussed. Because of the rarity of some of these conditions, limited information is available regarding infectious complications.

引用

页数：15

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