Mechanism and treatments of antipsychotic-induced weight gain

被引：13

作者：

Ye, Wujie ^{[1
]}

Xing, Jingyu ^{[1
]}

Yu, Zekai ^{[1
]}

Hu, Xingang ^{[2
]}

Zhao, Yan ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Internal Encephalopathy Tradit Chinese Med, Dongfang Hosp, Beijing 100078, Peoples R China

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2023年 / 47卷 / 06期

关键词：

NEUROTROPHIC FACTOR BDNF; 5-HT2C RECEPTOR GENE; INSULIN-RESISTANCE; DOUBLE-BLIND; BODY-WEIGHT; FOOD-INTAKE; ATYPICAL ANTIPSYCHOTICS; ENDOCANNABINOID SYSTEM; BIPOLAR DISORDER; GUT-MICROBIOTA;

D O I：

10.1038/s41366-023-01291-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The long-term use of antipsychotics (APs) may cause a variety of diseases, such as metabolic syndrome, antipsychotic-induced weight gain (AIWG), and even obesity. This paper reviews the various mechanisms of AIWG and obesity in detail, involving genetics, the central nervous system, the neuroendocrine system, and the gut microbiome. The common drug and non-drug therapies used in clinical practice are also introduced, providing the basis for research on the molecular mechanisms and the future selection of treatments.

引用

页码：423 / 433

页数：11

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