Supercritical fluid chromatography is not (only) normal-phase chromatography

被引:8
作者
West, Caroline [1 ]
机构
[1] Univ Orleans, Inst Organ & Analyt Chem, CNRS UMR7311, Rue Chartres,BP 6759, F-45067 Orleans, France
关键词
Elution strength; Normal; -phase; Retention mechanisms; Reversed-phase; Supercritical fluid chromatography; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLVATION PARAMETER MODEL; STATIONARY PHASES; CARBON-DIOXIDE; ENANTIOSELECTIVE SEPARATIONS; DISTRIBUTION ISOTHERMS; RETENTION BEHAVIOR; MOBILE-PHASE; VALIDATION; MODIFIERS;
D O I
10.1016/j.chroma.2023.464546
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Supercritical fluid chromatography (SFC), now using carbon dioxide as a major component of the mobile phase, has been known for over 60 years but still some misunderstandings remain about its capabilities. Amongst them, SFC is often described as a normal-phase chromatographic technique, based on different considerations: polarity of the stationary phase, elution order of the analytes, relative non-polarity of the mobile phase, non-linear retention behaviour, or adsorption retention mechanisms. All of these assumptions are true to a certain extent, and in certain circumstances. But also, all of these assumptions are wrong in different circumstances. In this paper, the criteria to categorize SFC as a normal-phase chromatographic method will be examined individually, considering all knowledge acquired from the early years of its development. Finally, it will appear that the "normal-phase" glass lens is greatly reducing the true extent of SFC's possibilities.
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页数:9
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