Self-Assembled nanoparticles of natural bioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma

被引:11
作者
Li, Yong [1 ]
Zhao, Qingyu [1 ]
Zhu, Xinyi [1 ]
Zhou, Long [1 ]
Song, Ping [1 ]
Liu, Baohui [1 ]
Tian, Daofeng [1 ]
Chen, Qianxue [1 ]
Zhou, Jiangbing [2 ]
Deng, Gang [1 ]
机构
[1] Wuhan Univ, Dept Neurosurg, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China
[2] Yale Univ, Dept Neurosurg, New Haven 06510, CT USA
基金
中国国家自然科学基金;
关键词
chemoresistance; glioblastoma; natural bioactive molecules; paclitaxel; P-glycoprotein; self-assembled nanoparticles; CANCER; CHEMOTHERAPY; MECHANISMS; EXPRESSION; RESISTANCE; PRODUCTS; PATHWAY;
D O I
10.1111/cns.14528
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Paclitaxel (PTX) is a well-established and highly effective anti-cancer drug for peripheral solid tumors. However, the application of PTX in GBM is hindered by several limitations, including poor water solubility, restricted entry across the blood-brain barrier (BBB), and enhanced excretion by efflux transporters. P-glycoprotein (P-gp) is a crucial efflux transporter that is abundantly present in cerebral vascular endothelial cells and GBM cells. It plays a significant role in the exocytosis of PTX within tumor tissues. Methods: Recently, we have developed a novel technique for creating self-assembled nanoparticles utilizing a range of natural bioactive molecules. These nanoparticles can encapsulate insoluble drugs and effectively cross the BBB. In additional, we revealed that certain nanoparticles have the potential to act as P-gp inhibitors, thereby reducing the excretion of PTX. In this study, we conducted a screening of bioactive molecular nanoparticles to identify those that effectively inhibit the function of P-gp transporters. Results: Among the candidates, we identified ursolic acid nanoparticles (UA NPs) as the P-gp inhibitors. Furthermore, we prepared co-assembled UA NPs embedded with paclitaxel, referred to as UA-PTX NPs. Our results demonstrate that UA-PTX NPs can enhance the blood concentration of PTX, facilitate its entry into the BBB, and inhibit the function of P-gp, resulting in a decrease in the excretion of PTX. This discovery effectively addressed the above three issues associated with the use of PTX in glioma treatment. Conclusions: UA-PTX NPs demonstrate strong anti-tumor effects and show great potential for treating GBM.
引用
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页数:12
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