Paradoxical role of phosphorylated STAT3 in normal fertility and the pathogenesis of adenomyosis and endometriosis

被引:2
作者
Xu, Yichi [1 ,2 ]
Wu, Fan [1 ]
Qin, Chuanmei [1 ]
Lin, Yi [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Reprod Med Ctr, Sch Med, 600 Yishan Rd, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai Key Lab Embryo Original Dis, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
STAT3; decidualization; endometrial receptivity; embryo implantation; adenomyosis; endometriosis; LEUKEMIA INHIBITORY FACTOR; SIGNAL TRANSDUCER; TRANSCRIPTION-3; STAT3; EMBRYO IMPLANTATION; CELL-PROLIFERATION; PREVENTS IMPLANTATION; PROGESTERONE-RECEPTOR; CYTOKINE RECEPTOR; ACTIVATION; EXPRESSION;
D O I
10.1093/biolre/ioad148
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Signal transducer and activator of transcription 3 (STAT3), when phosphorylated at tyrosine 705, plays an important role in endometrial stromal cell decidualization and the receptivity of the endometrial epithelium during embryo implantation. However, the function of phosphorylated STAT3 (p-STAT3) in normal uterine receptivity is distinct from that in adenomyosis and endometriosis. In normal pregnancy, STAT3 phosphorylation in the endometrial epithelium determines the success of embryo implantation by regulating uterine receptivity. Additionally, p-STAT3 promotes cellular proliferation and differentiation during endometrial decidualization, which is crucial for embryonic development. In contrast, excessive STAT3 phosphorylation occurs in adenomyosis and endometriosis, which may lead to disease progression. Therefore, achieving a delicate balance in STAT3 activation is crucial. This review aimed to focus on the current understanding and knowledge gaps regarding the control of p-STAT3 activity in normal and pathological endometrial processes. This topic is important because precise control of p-STAT3 production could alleviate the symptoms of adenomyosis and endometriosis, improve endometrial receptivity, and potentially mitigate infertility without compromising normal fertility processes.
引用
收藏
页码:5 / 13
页数:9
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