PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

被引：7

作者：

Dong, Hongmei ^{[1
,2
,3
,4
]}

Lin, Wan ^{[5
]}

Du, Liang ^{[6
]}

Yao, Zhimeng ^{[1
,2
,3
,7
]}

Li, Feifei ^{[8
]}

Chen, Shuanglong ^{[1
,2
,3
]}

Huang, Yiteng ^{[9
]}

Ren, Hongzheng ^{[10
,11
]}

Luo, Yichen ^{[1
,2
,3
]}

Cai, Songwang ^{[12
]}

Chen, Yexi ^{[13
]}

Tang, Hui ^{[14
,15
]}

Qiu, Xiaofu ^{[16
]}

Pan, Yunlong ^{[4
]}

Huang, Xingxu ^{[17
]}

Zhang, Dianzheng ^{[18
]}

Gao, Shegan ^{[19
,23
]}

Yeung, Sai-Ching Jim ^{[20
,21
,24
]}

Zhang, Hao ^{[4
,22
]}

机构：

[1] Jinan Univ, Inst Precis Canc Med & Pathol, Guangzhou, Peoples R China

[2] Jinan Univ, Sch Med, Dept Pathol, Guangzhou, Guangdong, Peoples R China

[3] Jinan Univ, Minister Educ, Key Lab Tumor Mol Biol, Guangzhou, Guangdong, Peoples R China

[4] Jinan Univ, Dept Gen Surg, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[5] Shantou Univ, Canc Res Ctr, Med Coll, Shantou, Guangdong, Peoples R China

[6] Chongqing Univ, Canc Hosp, Radiat Oncol Ctr, Chongqing, Peoples R China

[7] Jinan Univ, Affiliated Hosp 1, Dept Urol Surg, Guangzhou, Guangdong, Peoples R China

[8] Peoples Hosp Leshan, Dept Oncol, Leshan, Sichuan, Peoples R China

[9] Shantou Univ, Hlth Care Ctr, Affiliated Hosp 1, Med Coll, Shantou, Guangdong, Peoples R China

[10] Naval Med Univ, Gongli Hosp, Dept Pathol, Shanghai, Peoples R China

[11] Changzhi Med Coll, Dept Pathol, Heping Hosp, Changzhi, Shanxi, Peoples R China

[12] Jinan Univ, Dept Thorac Surg, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[13] Shantou Univ, Dept Gen Surg, Affiliated Hosp 2, Med Coll, Shantou, Guangdong, Peoples R China

[14] Jinan Univ, Dept Cent Lab, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[15] Jinan Univ, Heyuan Shenhe Peoples Hosp, Dept Clin Lab, Affiliated Hosp 5, Heyuan, Peoples R China

[16] Guangdong Second Prov Gen Hosp, Dept Urol, Guangzhou, Guangdong, Peoples R China

[17] Nanjing Univ, Model Anim Res Ctr, MOE, Key Lab Model Anim Dis Study, Nanjing, Jiangsu, Peoples R China

[18] Philadelphia Coll Osteopath Med, Dept Biomed Sci, Philadelphia, PA USA

[19] Henan Univ Sci & Technol, Coll Clin Med, Affiliated Hosp 1, Henan Key Lab Canc Epigenet, Luoyang 471003, Henan, Peoples R China

[20] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX USA

[21] Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX USA

[22] Jinan Univ, Dept Gen Surg, Affiliated Hosp 1, 613 Huangpu Ave West, Guangzhou 510630, Guangdong, Peoples R China

[23] Henan Univ Sci & Technol, Coll Clin Med, Affiliated Hosp 1, Henan Key Lab Canc Epigenet, Luoyang 471003, Henan, Peoples R China

[24] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2023年 / 567卷

关键词：

PTPRO; Tyrosine phosphatase; MET; Esophageal squamous cell carcinoma; Metastasis; RECEPTOR-TYROSINE KINASE; C-MET; GENE AMPLIFICATION; LUNG-CANCER; CELL; EGFR; CARCINOGENESIS; METHYLATION; RESISTANCE; MODEL;

D O I：

10.1016/j.canlet.2023.216283

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/ p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.

引用

页数：10

共 50 条

[21] Prediction of lymph node metastasis in early esophageal cancer
Li, Yan
Wang, Jun-Xiong
Yibi, Ran-Hen
WORLD JOURNAL OF GASTROINTESTINAL SURGERY, 2023, 15 (10): : 2294 - 2304
[22] Anlotinib suppresses metastasis and multidrug resistance via dual blockade of MET/ABCB1 in colorectal carcinoma cells
Yan, Lin-Hai
Zhang, Di
Mo, Si-Si
Yuan, Hao
Mo, Xian-Wei
Zhao, Jin-Min
JOURNAL OF CANCER, 2021, 12 (07): : 2092 - 2104
[23] Microcystic adnexal carcinoma with lymph node metastasis
Ban, M
Sugie, S
Kamiya, H
Kitajima, Y
DERMATOLOGY, 2003, 207 (04) : 395 - 397
[24] Retrospective analysis of predictive factors for lymph node metastasis in superficial esophageal squamous cell carcinoma
Ruan, Rongwei
Chen, Shengsen
Tao, Yali
Yu, Jiangping
Zhou, Danping
Cui, Zhao
Shen, Qiwen
Wang, Shi
SCIENTIFIC REPORTS, 2021, 11 (01)
[25] Evaluation of an indicator for lymph node metastasis of esophageal squamous cell carcinoma invading the submucosal layer
Nakajima, Y
Nagai, K
Miyake, S
Ohashi, K
Kawano, T
Iwai, T
JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (03): : 305 - 312
[26] Risk analysis of lymph node metastasis in 285 patients with superficial esophageal squamous cell carcinoma
李苗
ChinaMedicalAbstracts(InternalMedicine), 2016, 33 (03) : 162 - 162
[27] Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma
Yachida, Tatsuo
Oda, Ichiro
Abe, Seiichiro
Sekiguchi, Masau
Nonaka, Satoru
Suzuki, Haruhisa
Yoshinaga, Shigetaka
Taniguchi, Hirokazu
Sekine, Shigeki
Masugata, Hisashi
Masaki, Tsutomu
Daiko, Hiroyuki
Saito, Yutaka
DIGESTION, 2020, 101 (03) : 239 - 244
[28] Stratification of lymph node metastasis improves diagnostic efficiency in thoracic esophageal squamous cell carcinoma
Li, Zhenxuan
Li, Yin
Liu, Xianben
Zheng, Yan
Sun, Haibo
Liang, Guanghui
Wang, Zongfei
Xing, Wenqun
DISEASES OF THE ESOPHAGUS, 2023, 36 (09)
[29] Development and validation of a nomogram for prediction of cervical lymph node metastasis in middle and lower thoracic esophageal squamous cell carcinoma
Yan, Zhaoyang
Xu, Xinjian
Lu, Juntao
You, Yang
Xu, Jinsheng
Xu, Tongxin
BMC GASTROENTEROLOGY, 2022, 22 (01)
[30] Effect of cervical paraesophageal lymph node metastasis versus supraclavicular lymph node metastasis on the overall survival of patients with thoracic esophageal squamous cell carcinoma: an observational study
Li, Kexun
Li, Changding
Lu, Simiao
He, Wenwu
Wang, Chenghao
Han, Yongtao
Leng, Xuefeng
Peng, Lin
ANNALS OF MEDICINE AND SURGERY, 2024, 86 (05): : 2518 - 2523

← 1 2 3 4 5 →