Applications of radiolabeled antibodies in neuroscience and neuro-oncology

被引：2

作者：

Pakula, Ryan J. ^{[1
]}

Scott, Peter J. H. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Radiol, Ann Arbor, MI USA

[2] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2023年 / 66卷 / 09期

关键词：

immunotherapy; molecular imaging; neuro-oncology; neuroscience; radiolabeled antibodies; radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; BLOOD-BRAIN-BARRIER; MONOCLONAL-ANTIBODIES; ALZHEIMERS-DISEASE; NUCLEAR-MEDICINE; CLINICAL-TRIALS; IMMUNO-PET; RECEPTOR; THERANOSTICS; BINDING;

D O I：

10.1002/jlcr.4049

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Positron emission tomography (PET) is a powerful tool in medicine and drug development, allowing for non-invasive imaging and quantitation of biological processes in live organisms. Targets are often probed with small molecules, but antibody-based PET is expanding because of many benefits, including ease of design of new antibodies toward targets, as well as the very strong affinities that can be expected. Application of antibodies to PET imaging of targets in the central nervous system (CNS) is a particularly nascent field, but one with tremendous potential. In this review, we discuss the growth of PET in imaging of CNS targets, present the promises and progress in antibody-based CNS PET, explore challenges faced by the field, and discuss questions that this promising approach will need to answer moving forward for imaging and perhaps even radiotherapy.

引用

页码：269 / 285

页数：17

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