Transition-metal-free Synthesis of tetra-substituted Vinyl Iodides by Cascade Sequential Reaction of a-Keto Acids, 1-Iodoalkynes, and Alkyl Halides

被引：0

作者：

Zeng, Xiaobao ^{[1
]}

Cheng, Zhenfeng ^{[1
]}

Xie, Yushan ^{[1
]}

Gu, Yunhui ^{[1
]}

机构：

[1] Nantong Univ, Sch Pharm, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2023年 / 18卷 / 02期

关键词：

transition-metal-free; cascade sequential reaction; terta-substituted vinyl iodides; 1-iodoalkynes; alpha-keto acids; BAYLIS-HILLMAN ESTERS; GAMMA-HYDROXYBUTENOLIDES; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; DOUBLE-BONDS; ANNULATION; HALOALKYNES; BUTENOLIDES; ACCESS; ARYL;

D O I：

10.1002/asia.202201117

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cascade sequential reaction of alpha-keto acids, 1-iodoalkynes, and alkyl halides are reported herein to synthesize tetra-substituted vinyl iodides. It represents an efficient protocol to access a diverse range of tetra-substituted vinyl iodides starting from simple materials in a one-pot fashion, featuring mild reaction conditions, ease of operation, and broad substrate scope.

引用

页数：7

共 3 条

[1] Transition-Metal-Free Synthesis of Unsymmetrical Disulfides via Three-Component Reaction of Thiosulfonates, Thiourea and Alkyl halides
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ADVANCED SYNTHESIS & CATALYSIS, 2021, 363 (11) : 2767 - 2772
[2] Aqueous Synthesis of 1-H-2-Substituted Benzimidazoles via Transition-Metal-Free Intramolecular Amination of Aryl Iodides
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[3] One-pot synthesis of 1,2,3-triazoles from benzyl and alkyl halides, sodium azide and alkynes in water under transition-metal-catalyst free reaction conditions
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LETTERS IN ORGANIC CHEMISTRY, 2007, 4 (01) : 23 - 26

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