LncRNA LINC01339 Hinders the Development of Wilms' Tumor via MiR-135b-3p/ADH1C Axis

被引:2
作者
Yu, Yang [1 ]
Liu, Yanfei [2 ,3 ]
机构
[1] Wuhan Univ Sci & Technol, Dept Nephrol, Puren Hosp, Wuhan, Peoples R China
[2] Wuhan Univ Sci & Technol, Dept Oncol, Puren Hosp, Wuhan, Peoples R China
[3] Wuhan Univ Sci & Technol, Dept Oncol, Puren Hosp, 1 Benxi St, Wuhan 430080, Peoples R China
关键词
Wilms' tumor; ADH1C; LINC01339; lncRNA; miR-135b-3p; COLORECTAL-CANCER; NONCODING RNAS; ADH1B; EXPRESSION; MIGRATION; INVASION; RISK; POLYMORPHISMS; MICRORNAS; PROMOTES;
D O I
10.1055/a-2184-8945
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Wilms' tumor is a malignant renal cancer that arises within the pediatric urinary system. This study intended to investigate how a novel long non-coding RNA LINC01339 functions in the pathogenesis of Wilms' tumor. An elevated miR-135b-3p expression as well as reduced levels of LINC01339 and ADH1C were observed in Wilms' tumor. LINC01339 mediated ADH1C expression by directly binding to miR-135b-3p. The enforced LINC01339 or ADH1C markedly hindered cell growth and migration in Wilms' tumor. The LINC01339 overexpression also repressed the growth of Wilms' tumors in vivo, whereas miR-135b-3p overexpression exerted the opposite effects on Wilms' tumor cells in vitro. Additionally, upregulating miR-135b-3p reversed LINC01339's effects on the cellular processes of Wilms' tumor cells, whereas ADH1C overexpression offset the cancer-promoting influence of miR-135b-3p upregulation on Wilms' tumor progression. Therefore, LINC01339 prevents Wilms' tumor progression by modulating the miR-135b-3p/ADH1C axis. Our findings substantiate that the LINC01339/miR-135 b-3p/ADH1C regulatory axis has potential to be a target for the treatment of Wilms' tumor.
引用
收藏
页码:244 / 254
页数:11
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