Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines

被引：68

作者：

Swetha, K. ^{[1
]}

Kotla, Niranjan G. ^{[2
]}

Tunki, Lakshmi ^{[3
,4
]}

Jayaraj, Arya ^{[1
]}

Bhargava, Suresh K. ^{[4
]}

Hu, Haitao ^{[5
,6
]}

Bonam, Srinivasa Reddy ^{[5
]}

Kurapati, Rajendra ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Sch Chem, Thiruvananthapuram 695551, India

[2] Saveetha Univ, Saveetha Sch Engn, Saveetha Inst Med & Tech Sci, Chennai 602105, India

[3] CSIR Indian Inst Chem Technol, Dept Appl Biol, Hyderabad 500007, India

[4] RMIT Univ, Sch Sci, Ctr Adv Mat & Ind Chem CAM, Melbourne, Vic 3001, Australia

[5] Univ Texas Med Branch, Dept Microbiol & Immunol, 301 Univ Blvd, Galveston, TX 77555 USA

[6] Univ Texas Med Branch, Inst Human Infect & Immun, Sealy Inst Vaccine Sci, Galveston, TX 77555 USA

来源：

VACCINES | 2023年 / 11卷 / 03期

关键词：

vaccine; mRNA; COVID-19; lipid nanoparticles; TRANSFECTION EFFICIENCY; SYSTEMIC DELIVERY; IN-VIVO; THERAPEUTICS; FORMULATIONS; PEGYLATION; DESIGN; INNATE; CANCER;

D O I：

10.3390/vaccines11030658

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery. LNPs comprise four different lipids: ionizable lipids, helper or neutral lipids, cholesterol, and lipids attached to polyethylene glycol (PEG). In this review, we present recent the advances and insights for the design of LNPs, as well as their composition and properties, with a subsequent discussion on the development of COVID-19 vaccines. In particular, as ionizable lipids are the most critical drivers for complexing the mRNA and in vivo delivery, the role of ionizable lipids in mRNA vaccines is discussed in detail. Furthermore, the use of LNPs as effective delivery vehicles for vaccination, genome editing, and protein replacement therapy is explained. Finally, expert opinion on LNPs for mRNA vaccines is discussed, which may address future challenges in developing mRNA vaccines using highly efficient LNPs based on a novel set of ionizable lipids. Developing highly efficient mRNA delivery systems for vaccines with improved safety against some severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants remains difficult.

引用

页数：18

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