Emerging concepts in neuropathic and neurogenic itch

被引：13

作者：

Auyeung, Kelsey L. ^{[1
]}

Kim, Brian S. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Kimberly & Eric J Waldman Dept Dermatol, New York, NY USA

[2] Icahn Sch Med Mt Sinai, Mark Lebwohl Ctr Neuroinflammat & Sensat, New York, NY USA

[3] Icahn Sch Med Mt Sinai, Marc & Jennifer Lipschultz Precis Immunol Inst, New York, NY USA

[4] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA

[5] Icahn Med Inst, 1425 Madison Ave,Room L12-75A, New York, NY 10029 USA

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2023年 / 131卷 / 05期

关键词：

ATOPIC-DERMATITIS; DOUBLE-BLIND; PRURIGO NODULARIS; MAST-CELL; PLACEBO; ADOLESCENTS; NEMOLIZUMAB; SENSATION; DUPILUMAB; INSIGHTS;

D O I：

10.1016/j.anai.2023.08.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Chronic pruritus has multiple etiologies, ranging from inflammatory to metabolic and neuropathic processes. However, recent advances in itch biology have shed light on potential mechanisms that explain the molecular and cellular basis of these pathologies. Furthermore, new understanding of neuroimmune itch circuits necessi-tates clarification of terminologies such as "neuropathic" and "neurogenic." This review provides an overview of ways new concepts may better explain the pathophysiology of a variety of chronic pruritic disorders and the rationale for directing emerging novel therapeutic strategies toward them. (c) 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. This is an open access arti-cle under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

引用

页码：561 / 566

页数：6

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