Maximizing the Clinical Value of Blood-Based Biomarkers for Mild Traumatic Brain Injury

被引:3
作者
Rauchman, Steven H. [1 ]
Pinkhasov, Aaron [2 ]
Gulkarov, Shelly [2 ]
Placantonakis, Dimitris G. [3 ]
De Leon, Joshua [2 ]
Reiss, Allison B. [2 ]
机构
[1] Fresno Inst Neurosci, Fresno, CA 93730 USA
[2] NYU, Dept Surg, Grossman Long Isl Sch Med, Mineola, NY 11501 USA
[3] NYU, Dept Neurosurg, Grossman Sch Med, New York, NY 10016 USA
关键词
concussion; mild traumatic brain injury; biomarker; diagnosis; GFAP; rehabilitation; DIFFUSE AXONAL INJURY; CONCUSSION; PROTEIN; MRI; CLASSIFICATION; EPIDEMIOLOGY; PERFORMANCE; PREDICTION; MORTALITY; DIAGNOSIS;
D O I
10.3390/diagnostics13213330
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mild traumatic brain injury (TBI) and concussion can have serious consequences that develop over time with unpredictable levels of recovery. Millions of concussions occur yearly, and a substantial number result in lingering symptoms, loss of productivity, and lower quality of life. The diagnosis may not be made for multiple reasons, including due to patient hesitancy to undergo neuroimaging and inability of imaging to detect minimal damage. Biomarkers could fill this gap, but the time needed to send blood to a laboratory for analysis made this impractical until point-of-care measurement became available. A handheld blood test is now on the market for diagnosis of concussion based on the specific blood biomarkers glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl terminal hydrolase L1 (UCH-L1). This paper discusses rapid blood biomarker assessment for mild TBI and its implications in improving prediction of TBI course, avoiding repeated head trauma, and its potential role in assessing new therapeutic options. Although we focus on the Abbott i-STAT TBI plasma test because it is the first to be FDA-cleared, our discussion applies to any comparable test systems that may become available in the future. The difficulties in changing emergency department protocols to include new technology are addressed.
引用
收藏
页数:14
相关论文
共 136 条
[1]  
Abbott Receives, 2023, News Release
[2]   Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury [J].
Abdullah, Aimi Nadhiah ;
Ahmad, Asma Hayati ;
Zakaria, Rahimah ;
Tamam, Sofina ;
Abd Hamid, Aini Ismafairus ;
Chai, Wen Jia ;
Omar, Hazim ;
Rahman, Muhammad Riddha Abdul ;
Fitzrol, Diana Noma ;
Idris, Zamzuri ;
Ghani, Abdul Rahman Izaini ;
Wan Mohamad, Wan Nor Azlen ;
Mustafar, Faiz ;
Hanafi, Muhammad Hafiz ;
Reza, Mohamed Faruque ;
Umar, Hafidah ;
Mohd Zulkifly, Mohd Faizal ;
Ang, Song Yee ;
Zakaria, Zaitun ;
Musa, Kamarul Imran ;
Othman, Azizah ;
Embong, Zunaina ;
Sapiai, Nur Asma ;
Kandasamy, Regunath ;
Ibrahim, Haidi ;
Abdullah, Mohd Zaid ;
Amaruchkul, Kannapha ;
Valdes-Sosa, Pedro Antonio ;
Bringas Vega, Maria Luisa ;
Biswal, Bharat ;
Songsiri, Jitkomut ;
Yaacob, Hamwira Sakti ;
Sumari, Putra ;
Noh, Nor Azila ;
Azman, Azlinda ;
Singh, Paramjit Singh Jamir ;
Abdullah, Jafri Malin .
FRONTIERS IN NEUROLOGY, 2022, 13
[3]   Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study [J].
Agoston, Denes V. ;
McCullough, Jesse ;
Aniceto, Roxanne ;
Lin, I-Hsuan ;
Kamnaksh, Alaa ;
Eklund, Michael ;
Graves III, Wallace M. M. ;
Dunbar, Cyrus ;
Engall, James ;
Schneider, Eric B. ;
Leonessa, Fabio ;
Duckworth, Josh L. .
NEUROTRAUMA REPORTS, 2022, 3 (01) :479-490
[4]   Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study [J].
Akerlund, Cecilia A., I ;
Holst, Anders ;
Stocchetti, Nino ;
Steyerberg, Ewout W. ;
Menon, David K. ;
Ercole, Ari ;
Nelson, David W. .
CRITICAL CARE, 2022, 26 (01)
[5]   Heads Up! Interlinked Amyloidogenic and Axonal Transport Pathways in Concussion-Induced Neurodegeneration [J].
Almenar-Queralt, Angels ;
Chaves, Rodrigo dos Santos ;
Kwon, Ester J. ;
Shah, Sameer B. .
NEUROSCIENCE INSIGHTS, 2022, 17
[6]   S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy [J].
Amoo, Michael ;
Henry, Jack ;
O'Halloran, Philip J. ;
Brennan, Paul ;
Ben Husien, Mohammed ;
Campbell, Matthew ;
Caird, John ;
Javadpour, Mohsen ;
Curley, Gerard F. .
NEUROSURGICAL REVIEW, 2022, 45 (02) :1171-1193
[7]   Immediate effects of an acute bout of repeated soccer heading on cognitive performance [J].
Ashton, Jake ;
Coyles, Ginny ;
Malone, James J. ;
Roberts, James W. .
SCIENCE AND MEDICINE IN FOOTBALL, 2021, 5 (03) :181-187
[8]   Acute Effects of Sport-Related Concussion on Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase L1, Total Tau, and Neurofilament Light Measured by a Multiplex Assay [J].
Asken, Breton M. ;
Yang, Zhihui ;
Xu, Haiyan ;
Weber, Arthur G. ;
Hayes, Ronald L. ;
Bauer, Russell M. ;
DeKosky, Steven T. ;
Jaffee, Michael S. ;
Wang, Kevin K. W. ;
Clugston, James R. .
JOURNAL OF NEUROTRAUMA, 2020, 37 (13) :1537-1545
[9]  
Asken BM, 2016, J ATHL TRAINING, V51, P329, DOI 10.4085/1062-6050-51.5.02
[10]   Blood neurofilament light: a critical review of its application to neurologic disease [J].
Barro, Christian ;
Chitnis, Tanuja ;
Weiner, Howard L. .
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2020, 7 (12) :2508-2523