Visible-Light-Mediated Solvent-Switched Photosensitizer-Free Synthesis of Polyfunctionalized Quinolines and Pyridines

被引：11

作者：

Dhara, Hirendra Nath ^{[1
]}

Rakshit, Amitava ^{[1
]}

Alam, Tipu ^{[1
]}

Sahoo, Ashish Kumar ^{[1
]}

Patel, Bhisma K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, North Guwahati 781039, India

来源：

ORGANIC LETTERS | 2023年

关键词：

INHIBITORY-ACTIVITY; NITRILES; ACIDS;

D O I：

10.1021/acs.orglett.2c04027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solvent (2,2,2-trifluoroethanol (TFE) vs ethyl alcohol (EtOH)) switched synthesis of quinolines and pyridines is illustrated from (E)-2-(1,3-diphenylallylidene)malononitriles via a Pd(II)-catalyzed photochemical process. The active catalyst [L2Pd(0)] generated serves as an exogenous photosensitizer. The process offers predominantly Z-alkenylated quinolines and pyridines in TFE and EtOH, respectively. Furthermore, large-scale synthesis and a few interesting post-synthetic modifications have been demonstrated.

引用

页码：471 / 476

页数：6