Post-hospitalization rehabilitation alleviates long-term immune repertoire alteration in COVID-19 convalescent patients

被引：6

作者：

Feng, Bing ^{[1
,2
,3
,4
,5
]}

Zheng, Danwen ^{[1
,5
]}

Yang, Laijun ^{[1
,5
]}

Su, Zuqing ^{[1
,2
,3
,4
,5
]}

Tang, Lipeng ^{[1
,2
,3
,4
,5
]}

Zhu, Ying ^{[1
,2
,3
,4
,5
]}

Xu, Xiaohua ^{[1
,5
]}

Wang, Qian ^{[1
,5
]}

Lin, Qiaoli ^{[1
,2
]}

Hu, Jiajun ^{[1
,5
]}

Lin, Meixuan ^{[1
,5
]}

Huang, Liqun ^{[1
,5
]}

Zhou, Xin ^{[1
,5
]}

Liu, Han ^{[1
]}

Li, Song ^{[6
,7
]}

Pan, Wenjing ^{[6
]}

Shi, Rongdong ^{[1
,5
]}

Lu, Yanjing ^{[1
,5
]}

Wu, Bin ^{[1
]}

Ding, Banghan ^{[1
]}

Wang, Zhe ^{[1
,8
]}

Guo, Jianwen ^{[1
,2
,3
,4
,5
,8
]}

Zhang, Zhongde ^{[1
,2
,3
,4
,8
]}

Zheng, Guangjuan ^{[1
,2
,3
,4
,5
,8
]}

Liu, Yuntao ^{[1
,3
,5
,8
]}

机构：

[1] Guangdong Prov Hosp Chinese Med & Guangdong Prov A, Guangzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong, Guangdong, Peoples R China

[3] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China

[4] Guangdong Prov Key Lab Chinese Med Prevent & Treat, Guangzhou, Peoples R China

[5] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China

[6] Hunan Univ Technol, Hunan Key Lab Biomed Nanomat & Devices, Zhuzhou, Peoples R China

[7] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China

[8] Guangdong Prov Hosp Chinese Med & Guangdong Prov A, Guangzhou 510120, Peoples R China

来源：

CELL PROLIFERATION | 2023年 / 56卷 / 10期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CELL; GENERATION; RESPONSES; OUTCOMES;

D O I：

10.1111/cpr.13450

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The global pandemic of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an once-in-a-lifetime public health crisis. Among hundreds of millions of people who have contracted with or are being infected with COVID-19, the question of whether COVID-19 infection may cause long-term health concern, even being completely recovered from the disease clinically, especially immune system damage, needs to be addressed. Here, we performed seven-chain adaptome immune repertoire analyses on convalescent COVID-19 patients who have been discharged from hospitals for at least 6 months. Surprisingly, we discovered lymphopenia, reduced number of unique CDR3s, and reduced diversity of the TCR/BCR immune repertoire in convalescent COVID-19 patients. In addition, the BCR repertoire appears to be activated, which is consistent with the protective antibody titres, but serological experiments reveal significantly lower IL-4 and IL-7 levels in convalescent patients compared to those in healthy controls. Finally, in comparison with convalescent patients who did not receive post-hospitalization rehabilitation, the convalescent patients who received post-hospitalization rehabilitation had attenuated immune repertoire abnormality, almost back to the level of healthy control, despite no detectable clinic demographic difference. Overall, we report the potential long-term immunological impairment for COVID-19 infection, and correction of this impairment via post-hospitalization rehabilitation may offer a new prospect for COVID-19 recovery strategy.

引用

页数：16