Post-hospitalization rehabilitation alleviates long-term immune repertoire alteration in COVID-19 convalescent patients

被引:6
作者
Feng, Bing [1 ,2 ,3 ,4 ,5 ]
Zheng, Danwen [1 ,5 ]
Yang, Laijun [1 ,5 ]
Su, Zuqing [1 ,2 ,3 ,4 ,5 ]
Tang, Lipeng [1 ,2 ,3 ,4 ,5 ]
Zhu, Ying [1 ,2 ,3 ,4 ,5 ]
Xu, Xiaohua [1 ,5 ]
Wang, Qian [1 ,5 ]
Lin, Qiaoli [1 ,2 ]
Hu, Jiajun [1 ,5 ]
Lin, Meixuan [1 ,5 ]
Huang, Liqun [1 ,5 ]
Zhou, Xin [1 ,5 ]
Liu, Han [1 ]
Li, Song [6 ,7 ]
Pan, Wenjing [6 ]
Shi, Rongdong [1 ,5 ]
Lu, Yanjing [1 ,5 ]
Wu, Bin [1 ]
Ding, Banghan [1 ]
Wang, Zhe [1 ,8 ]
Guo, Jianwen [1 ,2 ,3 ,4 ,5 ,8 ]
Zhang, Zhongde [1 ,2 ,3 ,4 ,8 ]
Zheng, Guangjuan [1 ,2 ,3 ,4 ,5 ,8 ]
Liu, Yuntao [1 ,3 ,5 ,8 ]
机构
[1] Guangdong Prov Hosp Chinese Med & Guangdong Prov A, Guangzhou, Peoples R China
[2] Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong, Guangdong, Peoples R China
[3] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China
[4] Guangdong Prov Key Lab Chinese Med Prevent & Treat, Guangzhou, Peoples R China
[5] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China
[6] Hunan Univ Technol, Hunan Key Lab Biomed Nanomat & Devices, Zhuzhou, Peoples R China
[7] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China
[8] Guangdong Prov Hosp Chinese Med & Guangdong Prov A, Guangzhou 510120, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
CELL; GENERATION; RESPONSES; OUTCOMES;
D O I
10.1111/cpr.13450
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The global pandemic of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an once-in-a-lifetime public health crisis. Among hundreds of millions of people who have contracted with or are being infected with COVID-19, the question of whether COVID-19 infection may cause long-term health concern, even being completely recovered from the disease clinically, especially immune system damage, needs to be addressed. Here, we performed seven-chain adaptome immune repertoire analyses on convalescent COVID-19 patients who have been discharged from hospitals for at least 6 months. Surprisingly, we discovered lymphopenia, reduced number of unique CDR3s, and reduced diversity of the TCR/BCR immune repertoire in convalescent COVID-19 patients. In addition, the BCR repertoire appears to be activated, which is consistent with the protective antibody titres, but serological experiments reveal significantly lower IL-4 and IL-7 levels in convalescent patients compared to those in healthy controls. Finally, in comparison with convalescent patients who did not receive post-hospitalization rehabilitation, the convalescent patients who received post-hospitalization rehabilitation had attenuated immune repertoire abnormality, almost back to the level of healthy control, despite no detectable clinic demographic difference. Overall, we report the potential long-term immunological impairment for COVID-19 infection, and correction of this impairment via post-hospitalization rehabilitation may offer a new prospect for COVID-19 recovery strategy.
引用
收藏
页数:16
相关论文
共 75 条
[1]  
Arstila T P, 2000, Science, V288, P1135
[2]   Analysis of the B cell receptor repertoire in six immune-mediated diseases [J].
Bashford-Rogers, R. J. M. ;
Bergamaschi, L. ;
McKinney, E. F. ;
Pombal, D. C. ;
Mescia, F. ;
Lee, J. C. ;
Thomas, D. C. ;
Flint, S. M. ;
Kellam, P. ;
Jayne, D. R. W. ;
Lyons, P. A. ;
Smith, K. G. C. .
NATURE, 2019, 574 (7776) :122-+
[3]   IL-7 in SARS-CoV-2 Infection and as a Potential Vaccine Adjuvant [J].
Bekele, Yonas ;
Sui, Yongjun ;
Berzofsky, Jay A. .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[4]  
Bieberich Florian, 2021, Front Immunol, V12, P701085, DOI 10.3389/fimmu.2021.701085
[5]   Detailed Multiplex Analysis of SARS-CoV-2 Specific Antibodies in COVID-19 Disease [J].
Brynjolfsson, Siggeir F. ;
Sigurgrimsdottir, Hildur ;
Einarsdottir, Elin D. ;
Bjornsdottir, Gudrun A. ;
Armannsdottir, Brynja ;
Baldvinsdottir, Gudrun E. ;
Bjarnason, Agnar ;
Gudlaugsson, Olafur ;
Gudmundsson, Sveinn ;
Sigurdardottir, Sigurveig T. ;
Love, Arthur ;
Kristinsson, Karl G. ;
Ludviksson, Bjorn R. .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[6]   T-CELL ANTIGEN RECEPTOR GENES AND T-CELL RECOGNITION [J].
DAVIS, MM ;
BJORKMAN, PJ .
NATURE, 1988, 334 (6181) :395-402
[7]   Macrophages-regulating nanomedicines for sepsis therapy [J].
Deng, Jiali ;
Wang, Rui ;
Huang, Shu ;
Ding, Jinsong ;
Zhou, Wenhu .
CHINESE CHEMICAL LETTERS, 2023, 34 (03)
[8]   Six-month outcomes and effect of pulmonary rehabilitation among patients hospitalized with COVID-19: a retrospective cohort study [J].
Dun, Yaoshan ;
Liu, Chao ;
Ripley-Gonzalez, Jeffrey W. ;
Liu, Ping ;
Zhou, Nanjiang ;
Gong, Xun ;
You, Baiyang ;
Du, Yang ;
Liu, Jiyang ;
Li, Bo ;
Liu, Suixin .
ANNALS OF MEDICINE, 2021, 53 (01) :2099-2109
[9]   Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities [J].
Fouladseresht, Hamed ;
Ghamar Talepoor, Atefe ;
Eskandari, Nahid ;
Norouzian, Marzieh ;
Ghezelbash, Behrooz ;
Beyranvand, Mohammad Reza ;
Nejadghaderi, Seyed Aria ;
Carson-Chahhoud, Kristin ;
Kolahi, Ali-Asghar ;
Safiri, Saeid .
FRONTIERS IN IMMUNOLOGY, 2022, 12
[10]   Predictive monitoring and therapeutic immune biomarkers in the management of clinical complications of COVID-19 [J].
Fouladseresht, Hamed ;
Doroudchi, Mehrnoosh ;
Rokhtabnak, Najmeh ;
Abdolrahimzadehfard, Hossein ;
Roudgari, Amir ;
Sabetian, Golnar ;
Paydar, Shahram .
CYTOKINE & GROWTH FACTOR REVIEWS, 2021, 58 :32-48