Female patients delay seeking medical care with alcohol-associated acute pancreatitis

被引:0
作者
Jeon, Christie Y. [1 ,2 ,7 ]
Adeniran, Esther [1 ]
Stewart, Connor [1 ]
Papachristou, Georgios I. [3 ]
Pisegna, Joseph R. [4 ]
Kuc, Alma A. [4 ]
Buxbaum, James L. [5 ]
Pandol, Stephen J. [1 ]
Yadav, Dhiraj [6 ]
机构
[1] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA USA
[2] UCLA Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
[3] Ohio State Univ, Wexner Med Ctr, Div Gastroenterol Hepatol & Nutr, Columbus, OH USA
[4] VA Greater Los Angeles Healthcare Syst, Dept Med, Div Gastroenterol Hepatol & Parenteral Nutr, Los Angeles, CA USA
[5] Univ Southern Calif, Keck Sch Med, Dept Med, Div Gastroenterol, Los Angeles, CA USA
[6] Univ Pittsburgh, Sch Med, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA
[7] Cedars Sinai Med Ctr, 8700 Beverly Blvd,PDC 596B, Los Angeles, CA 90048 USA
关键词
Pancreatitis; Alcohol; Sex; Quality of life; Abdominal pain; QUALITY-OF-LIFE; ABDOMINAL-PAIN; MYOCARDIAL-INFARCTION; SYMPTOMS; PREVALENCE; EPIDEMIOLOGY; POPULATION; DECISION; WOMEN;
D O I
10.1016/j.pan.2023.08.001
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Objective: Alcohol consumption is increasing in women, who more frequently report abdominal symptoms compared to men. We aimed to examine differences in presentation of acute pancreatitis [AP] in male and female patients hospitalized with alcohol-associated AP. Methods: We analyzed 138 patients enrolled in an ongoing case-crossover study of alcohol-associated AP conducted across 5 medical centers in the U.S. Patients meeting the Revised Atlanta Classification of AP and who scored 3 or higher on the AUDIT-C instrument were invited to participate in the study and were interviewed while hospitalized with AP. Sex differences in the timing and type of pancreas-associated pain, alcohol consumption, clinical presentation, and quality of life were examined by Chi-squared tests, Wilcoxon rank sum tests and t-tests. Results: Female patients reported significantly longer interval from onset of pain to deciding to seek medical attention (median 40 h, interquartile range [IQR] 14, 74) as compared to males (14 h, IQR 4, 50; p = 0.005). While male patients were more likely to have been admitted to the intensive care unit [ICU] (21%) as compared to female patients (7%; p = 0.04), the incidence of SIRS or severe AP did not differ by sex. Quality of life measures as reported through the PROMIS-29 instrument were equally suboptimal in both sexes. Anxiety disorders were diagnosed more frequently among females (61%) than in males (41%, p = 0.009). Conclusion: In a large case series of alcohol-associated AP, we found that female patients delayed seeking medical care compared to males. However, there were no differences in the type, location and intensity of abdominal pain. (c) 2023 IAP and EPC. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:761 / 766
页数:6
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