Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study

被引：4

作者：

Chen, Cheng ^{[1
,2
]}

Yang, Keming ^{[3
,4
]}

Nan, Hongmei ^{[5
]}

Unverzagt, Frederick ^{[6
]}

McClure, Leslie A. ^{[7
]}

Irvin, Marguerite R. ^{[8
]}

Judd, Suzanne ^{[9
]}

Cushman, Mary ^{[10
]}

Mukaz, Debora Kamin ^{[10
]}

Klaunig, James E. ^{[11
]}

D'Alton, Mary E. ^{[1
]}

Kahe, Ka ^{[1
,2
,12
,13
]}

机构：

[1] Columbia Univ, Vagelos Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

[3] Massachusetts Gen Hosp, Dept Med, Clin & Translat Epidemiol Unit, Boston, MA USA

[4] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[5] Indiana Univ Purdue Univ Indianapolis, Richard M Fairbanks Sch Publ Hlth, Dept Global Hlth, Indianapolis, IN USA

[6] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN USA

[7] Drexel Univ, Dornsife Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA USA

[8] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA

[9] Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL USA

[10] Univ Vermont, Dept Med, Larner Coll Med, Burlington, VT USA

[11] Indiana Univ Bloomington, Sch Publ Hlth, Dept Environm & Occupat Hlth, Bloomington, IN USA

[12] Columbia Univ, Dept Obstet & Gynecol, Irving Med Ctr, 622 168th St,Suite 16-20, New York, NY 10032 USA

[13] Columbia Univ, Dept Epidemiol, Irving Med Ctr, 622 168th St,Suite 16-20, New York, NY 10032 USA

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2023年 / 38卷

基金：

美国国家卫生研究院;

关键词：

telomere length; cognitive decline; executive function; sex disparity; racial disparity; RACIAL-DIFFERENCES; STROKE; IMPAIRMENT; REASONS; RISK; DISEASE;

D O I：

10.1177/15333175231175797

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

IntroductionWe examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race.MethodsA total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination 10 years later. Cognitive function was assessed by a four-test battery every 2 years.ResultsIn multivariable-adjusted linear mixed models, longer baseline TL and smaller attrition/lengthening of TL over time were associated with better Animal Fluency Test score. Longer baseline TL was also linearly associated with better Letter Fluency Test score. The observed associations were consistently more pronounced in women than men and in Black compared to White participants.DiscussionTelomere length may be a biomarker that predicts long-term verbal fluency and executive function, particularly in women and Black Americans.

引用

页数：10

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