Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

被引：8

作者：

Antunes, Flavia Tasmin Techera ^{[1
,2
]}

Campos, Maria Martha ^{[3
]}

Ricardo Carvalho, Vanice de Paula ^{[4
]}

da Silva Junior, Claudio Antonio ^{[4
]}

Magno, Luiz Alexandre Viana ^{[5
]}

de Souza, Alessandra Hubner ^{[5
]}

Gomez, Marcus Vinicius ^{[4
]}

机构：

[1] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 1N4, Canada

[3] Pontificia Univ Catolica Rio Grande do Sul, Programa Posgrad Odontol, Escola Ciencias Saude & Vida, BR-90619900 Porto Alegre, RS, Brazil

[4] Fac Santa Casa BH, BR-30110005 Belo Horizonte, MG, Brazil

[5] Fac Ciencias Med Minas Gerais FCMMG, Programa Posgrad Ciencias Saude, BR-30110005 Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 11期

关键词：

analgesic; antinociception; calcium signaling; drug development; pain transmission; FAMILIAL HEMIPLEGIC MIGRAINE; CORTICAL SPREADING DEPRESSION; TRIAZOLE OXINDOLE TROX-1; HORN NEURONAL RESPONSES; DEPENDENT CA2+ CHANNELS; DORSAL-ROOT GANGLIA; RAT SENSORY NEURONS; DELIVERED N-TYPE; NEUROPATHIC PAIN; P/Q-TYPE;

D O I：

10.3390/ijms24119223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.

引用

页数：17

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