Predictive impact of prognostic nutritional index in patients with cancer treated with immune checkpoint inhibitors: a systematic review and meta-analysis

被引：3
作者：
Xu, Xin-Tian [1 ]
Qian, Yu [2 ]
Tian, Meng-Xing [3 ]
Ding, Chen-Chen [3 ]
Guo, Huan [3 ]
Tang, Jing [2 ]
Pi, Guo-Liang [4 ]
Wu, Yuan [4 ]
Dai, Zhu [3 ]
Jin, Xin [3 ]
机构：
[1] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Thorac Oncol, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Clin Nutr, Wuhan, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Radiat Oncol, Wuhan, Hubei, Peoples R China
来源：
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2023年 / 75卷 / 06期
关键词：
HEPATOCELLULAR-CARCINOMA; SINGLE-ARM; PEMBROLIZUMAB; MALNUTRITION; INFLAMMATION; SURVIVAL; RISK; MICROENVIRONMENT; MULTICENTER; BIOMARKERS;
D O I：
10.1080/01635581.2023.2203355
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A few previous studies have investigated the prognostic value of the prognostic nutritional index (PNI) in patients treated with immune checkpoint inhibitors (ICIs); however, the results are inconsistent. Therefore, this study aimed to clarify the prognostic significance of PNI. The PubMed, Embase, and Cochrane Library databases were searched. A meta-analysis of the impact of PNI on overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and rate of adverse events (AEs) in patients treated with ICIs was performed. Twenty-three studies involving 2,386 patients were included. Low PNI was associated with significantly poor OS (hazard ratio [HR] = 2.26, 95% confidence interval [CI]: 1.81-2.82, P < .001) and short PFS (HR = 1.75, 95% CI: 1.54-1.99, P < .001). Patients with low PNI tended to have a low ORR (odds ratio [OR] = 0.47, 95% CI: 0.34-0.65, P < .001) and DCR (OR = 0.43, 95% CI: 0.34-0.56, P < .001). However, the subgroup analysis demonstrated no significant association between PNI and survival time in patients receiving a programmed death ligand-1 inhibitor. PNI was significantly associated with survival time and treatment efficacy in patients treated with ICIs.
引用
收藏
页码：1413 / 1426
页数：14
相关论文
共 72 条
[1]   Frailty and malnutrition predictive of mortality risk in older patients with advanced colorectal cancer receiving chemotherapy [J].
Aaldriks, Ab A. ;
van der Geest, Lydia G. M. ;
Giltay, Erik J. ;
le Cessie, Saskia ;
Portielje, Johanneke E. A. ;
Tanis, Bea C. ;
Nortier, Johan W. R. ;
Maartense, Ed .
JOURNAL OF GERIATRIC ONCOLOGY, 2013, 4 (03) :218-226
[2]   Impact of Sarcopenia, BMI, and Inflammatory Biomarkers on Survival in Advanced Hepatocellular Carcinoma Treated With Anti-PD-1 Antibody [J].
Akce, Mehmet ;
Liu, Yuan ;
Zakka, Katerina ;
Martini, Dylan J. ;
Draper, Amber ;
Alese, Olatunji B. ;
Shaib, Walid L. ;
Wu, Christina ;
Wedd, Joel P. ;
Sellers, Marty T. ;
Bilen, Mehmet A. ;
El-Rayes, Bassel F. .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2021, 44 (02) :74-81
[3]   Predictive value of post-treatment C-reactive protein-to-albumin ratio in locally advanced non-small cell lung cancer patients receiving durvalumab after chemoradiotherapy [J].
Araki, Taisuke ;
Tateishi, Kazunari ;
Komatsu, Masamichi ;
Sonehara, Kei ;
Wasamoto, Satoshi ;
Koyama, Shigeru ;
Yoshiike, Fumiaki ;
Hama, Mineyuki ;
Nishie, Kenichi ;
Kondo, Daichi ;
Agatsuma, Toshihiko ;
Kato, Akane ;
Takata, Munetake ;
Kanda, Shintaro ;
Hanaoka, Masayuki ;
Koizumi, Tomonobu .
THORACIC CANCER, 2022, 13 (14) :2031-2040
[4]   Conserved pan-cancer microenvironment subtypes predict response to immunotherapy [J].
Bagaev, Alexander ;
Kotlov, Nikita ;
Nomie, Krystle ;
Svekolkin, Viktor ;
Gafurov, Azamat ;
Isaeva, Olga ;
Osokin, Nikita ;
Kozlov, Ivan ;
Frenkel, Felix ;
Gancharova, Olga ;
Almog, Nava ;
Tsiper, Maria ;
Ataullakhanov, Ravshan ;
Fowler, Nathan .
CANCER CELL, 2021, 39 (06) :845-+
[5]   First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study [J].
Balar, Arjun V. ;
Castellano, Daniel ;
O'Donnell, Peter H. ;
Grivas, Petros ;
Vuky, Jacqueline ;
Powles, Thomas ;
Plimack, Elizabeth R. ;
Hahn, Noah M. ;
de Wit, Ronald ;
Pang, Lei ;
Savage, Mary J. ;
Perini, Rodolfo F. ;
Keefe, Stephen M. ;
Bajorin, Dean ;
Bellmunt, Joaquim .
LANCET ONCOLOGY, 2017, 18 (11) :1483-1492
[6]   Pembrolizumab for Platinum- and Cetuximab-Refractory Head and Neck Cancer: Results From a Single-Arm, Phase II Study [J].
Bauml, Joshua ;
Seiwert, Tanguy Y. ;
Pfister, David G. ;
Worden, Francis ;
Liu, Stephen V. ;
Gilbert, Jill ;
Saba, Nabil F. ;
Weiss, Jared ;
Wirth, Lori ;
Sukari, Ammar ;
Kang, Hyunseok ;
Gibson, Michael K. ;
Massarelli, Erminia ;
Powell, Steven ;
Meister, Amy ;
Shu, Xinxin ;
Cheng, Jonathan D. ;
Haddad, Robert .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (14) :1542-+
[7]   Neutrophil-to-Lymphocyte Ratio to Predict the Efficacy of Immune Checkpoint Inhibitor in Upper Gastrointestinal Cancer [J].
Booka, Eisuke ;
Kikuchi, Hirotoshi ;
Haneda, Ryoma ;
Soneda, Wataru ;
Kawata, Sanshiro ;
Murakami, Tomohiro ;
Matsumoto, Tomohiro ;
Hiramatsu, Yoshihiro ;
Takeuchi, Hiroya .
ANTICANCER RESEARCH, 2022, 42 (06) :2977-2987
[8]   Five-Year Survival Outcomes With Nivolumab Plus Ipilimumab Versus Chemotherapy as First-Line Treatment for Metastatic Non-Small-Cell Lung Cancer in CheckMate 227 [J].
Brahmer, Julie R. ;
Lee, Jong-Seok ;
Ciuleanu, Tudor-Eliade ;
Bernabe Caro, Reyes ;
Nishio, Makoto ;
Urban, Laszlo ;
Audigier-Valette, Clarisse ;
Lupinacci, Lorena ;
Sangha, Randeep ;
Pluzanski, Adam ;
Burgers, Jacobus ;
Mahave, Mauricio ;
Ahmed, Samreen ;
Schoenfeld, Adam J. ;
Paz-Ares, Luis G. ;
Reck, Martin ;
Borghaei, Hossein ;
O'Byrne, Kenneth J. ;
Gupta, Ravi G. ;
Bushong, Judith ;
Li, Li ;
Blum, Steven I. ;
Eccles, Laura J. ;
Ramalingam, Suresh S. .
JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (06) :1200-+
[9]   Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis [J].
Bullock, Alex F. ;
Greenley, Sarah L. ;
McKenzie, Gordon A. G. ;
Paton, Lewis W. ;
Johnson, Miriam J. .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2020, 74 (11) :1519-1535
[10]   Another side of the association between body mass index (BMI) and clinical outcomes of cancer patients receiving programmed cell death protein-1 (PD-1)/Programmed cell death-ligand 1 (PD-L1) checkpoint inhibitors: A multicentre analysis of immune-related adverse events [J].
Cortellini, Alessio ;
Bersanelli, Melissa ;
Santini, Daniele ;
Buti, Sebastiano ;
Tiseo, Marcello ;
Cannita, Katia ;
Perrone, Fabiana ;
Giusti, Raffaele ;
De Tursi, Michele ;
Zoratto, Federica ;
Marconcini, Riccardo ;
Russano, Marco ;
Zeppola, Tea ;
Anesi, Cecilia ;
Filetti, Marco ;
Marchetti, Paolo ;
Botticelli, Andrea ;
Gelibter, Alain ;
De Galitiis, Federica ;
Vitale, Maria Giuseppa ;
Rastelli, Francesca ;
Tudini, Marianna ;
Silva, Rosa Rita ;
Atzori, Francesco ;
Chiari, Rita ;
Ricciuti, Biagio ;
De Giglio, Andrea ;
Migliorino, Maria Rita ;
Mallardo, Domenico ;
Vanella, Vito ;
Mosillo, Claudia ;
Bracarda, Sergio ;
Rinaldi, Silvia ;
Berardi, Rossana ;
Natoli, Clara ;
Ficorella, Corrado ;
Porzio, Giampiero ;
Ascierto, Paolo A. .
EUROPEAN JOURNAL OF CANCER, 2020, 128 :17-26
12345678