Low expression levels of miRNA-155 and miRNA-499a are associated with obesity in Type 2 diabetes

被引：2

作者：

Latini, Andrea ^{[1
]}

Benedittis, Giada De ^{[1
]}

Ciccacci, Cinzia ^{[2
]}

Novelli, Giuseppe ^{[1
,3
,4
]}

Spallone, Vincenza ^{[5
]}

Borgiani, Paola ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Genet Sect, I-00133 Rome, Italy

[2] St Camillus Int Univ Hlth Sci, UniCamillus, I-00131 Rome, Italy

[3] IRCCS NEUROMED, I-86077 Pozzilli, IS, Italy

[4] Univ Nevada, Sch Med, Dept Pharmacol, Reno, NV 89557 USA

[5] Univ Roma Tor Vergata, Dept Syst Med, Endocrinol Sect, I-00133 Rome, Italy

来源：

EPIGENOMICS | 2024年 / 16卷 / 02期

关键词：

microRNA; miR-155; miR-499a; obesity; Type; 2; diabetes; MIR-155; NEUROPATHY; DIAGNOSIS; RISK;

D O I：

10.2217/epi-2023-0320

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background & aims: This study investigated a possible correlation between three circulating miRNAs, previously observed to be associated to diabetic polyneuropathy, and the obesity condition. Methods & results: The expression levels of miR-128a, miR-155 and miR499a were evaluated in 49 participants with Type 2 diabetes, divided into different groups based on the presence or absence of obesity and central obesity. The analyses revealed a significant decrease of miR-155 and miR-499a expression levels in obese subjects. In particular, the reduction appears to be even more significant in Type 2 diabetes subjects with central obesity. Conclusion: The results suggest that these miRNAs could be involved in obesity-driven pathogenetic mechanisms.

引用

页码：85 / 91

页数：8

共 29 条

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