Low expression levels of miRNA-155 and miRNA-499a are associated with obesity in Type 2 diabetes

被引：0
作者：
Latini, Andrea [1 ]
Benedittis, Giada De [1 ]
Ciccacci, Cinzia [2 ]
Novelli, Giuseppe [1 ,3 ,4 ]
Spallone, Vincenza [5 ]
Borgiani, Paola [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Genet Sect, I-00133 Rome, Italy
[2] St Camillus Int Univ Hlth Sci, UniCamillus, I-00131 Rome, Italy
[3] IRCCS NEUROMED, I-86077 Pozzilli, IS, Italy
[4] Univ Nevada, Sch Med, Dept Pharmacol, Reno, NV 89557 USA
[5] Univ Roma Tor Vergata, Dept Syst Med, Endocrinol Sect, I-00133 Rome, Italy
来源：
EPIGENOMICS | 2024年 / 16卷 / 02期
关键词：
microRNA; miR-155; miR-499a; obesity; Type; 2; diabetes; MIR-155; NEUROPATHY; DIAGNOSIS; RISK;
D O I：
10.2217/epi-2023-0320
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Background & aims: This study investigated a possible correlation between three circulating miRNAs, previously observed to be associated to diabetic polyneuropathy, and the obesity condition. Methods & results: The expression levels of miR-128a, miR-155 and miR499a were evaluated in 49 participants with Type 2 diabetes, divided into different groups based on the presence or absence of obesity and central obesity. The analyses revealed a significant decrease of miR-155 and miR-499a expression levels in obese subjects. In particular, the reduction appears to be even more significant in Type 2 diabetes subjects with central obesity. Conclusion: The results suggest that these miRNAs could be involved in obesity-driven pathogenetic mechanisms.
引用
收藏
页码：85 / 91
页数：8
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