Post-transplantation cyclophosphamide as GVHD prophylaxis in allogenic hematopoietic stem cell transplantation: Recent advances and modification

被引：7

作者：

Li, Yun ^{[1
]}

Wang, Na ^{[1
]}

Zhang, Xiaoying ^{[1
]}

Cao, Yang ^{[1
]}

Zhang, Lingfeng ^{[1
]}

Liu, Aiguo ^{[2
]}

Zhang, Yicheng ^{[1
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430030, Hubei, Peoples R China

[3] Chinese Acad Med Sci, Key Lab Organ Transplantat, NHC Key Lab Organ Transplantat, Minist Educ, Wuhan, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, 1095 Jie Fang Ave, Wuhan 430030, Hubei, Peoples R China

来源：

BLOOD REVIEWS | 2023年 / 62卷

基金：

中国国家自然科学基金;

关键词：

Allogenic hematopoietic stem cell; transplantation; Post-transplantation cyclophosphamide; Antithymocyte globulin; Graft versus host disease; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; INTRATHYMIC CLONAL DELETION; SKIN ALLOGRAFT TOLERANCE; SEVERE APLASTIC-ANEMIA; PHASE-II TRIAL; SINGLE-AGENT; HAPLOIDENTICAL TRANSPLANTATION; HEMATOLOGIC MALIGNANCIES; DONOR TRANSPLANTATION;

D O I：

10.1016/j.blre.2023.101078

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Allogenic hematopoietic stem cell transplantation (allo-HSCT) is the most important therapeutic option for hematological disorders, although graft-versus-host disease (GVHD) remains the main cause of mortality. Post transplantation cyclophosphamide (PTCY) induces immune tolerance and is associated with a low incidence of GVHD and non-relapse mortality. Therefore, PTCY has emerged as a safe and effective GVHD prophylaxis in haploidentical transplantation and has been expanded to matched related or unrelated donor and mismatched unrelated donor HSCT. On the basis of current understanding of the mechanisms of PTCY and antithymocyte globulin (ATG) in the prevention of GVHD, growing evidence suggests that the combination of ATG and PTCY could improve allo-HSCT clinical outcomes. Further research will focus on optimizing PTCY regimens by modifying the timing of administration or adding other immunosuppressive agents.

引用

页数：9

共 88 条

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