Molecular pathways in the development of HPV-induced oropharyngeal cancer

被引：5

作者：

Ullah, Muhammad Ikram ^{[1
]}

Mikhailova, Maria V. ^{[2
]}

Alkhathami, Ali G. ^{[3
]}

Carbajal, Nestor Cuba ^{[4
]}

Zuta, Manuel Enrique Chenet ^{[5
]}

Rasulova, Irodakhon ^{[6
,7
]}

Najm, Mazin A. A. ^{[8
]}

Abosoda, Munther ^{[9
,10
,11
]}

Alsalamy, Ali ^{[12
]}

Deorari, Mahamedha ^{[13
]}

机构：

[1] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Sakaka 72388, Aljouf, Saudi Arabia

[2] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Dept Prosthet Dent, Moscow, Russia

[3] King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Abha, Saudi Arabia

[4] Univ Norbert Wiener, Gest Publ & Gobernabilidad, Lima, Peru

[5] Univ San Ignacio Loyola, Escuela Posgrad, Lima, Peru

[6] New Uzbekistan Univ, Sch Humanities Nat & Social Sci, 54 Mustaqillik Ave, Tashkent 100007, Uzbekistan

[7] Tashkent Pediat Med Inst, Dept Publ Hlth, Bogishamol St 223, Tashkent, Uzbekistan

[8] Al Ayen Univ, Coll Pharm, Pharmaceut Chem Dept, Thi Qar, Iraq

[9] Islamic Univ, Coll Pharm, Najaf, Iraq

[10] Islamic Univ Al Diwaniyah, Coll Pharm, Al Diwaniyah, Iraq

[11] Islamic Univ Babylon, Coll Pharm, Hillah, Iraq

[12] Imam Jaafar Al Sadiq Univ, Coll Pharm, Muthanna 66002, Iraq

[13] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun 248001, Uttarakhand, India

来源：

CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期

关键词：

Oropharyngeal Cancer; HPV; Molecular Pathways; Carcinogenesis; Oncoproteins; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS INFECTION; RISK HUMAN-PAPILLOMAVIRUS; NECK-CANCER; ORAL-CAVITY; EPIDEMIOLOGY; POPULATION; HEAD; ALCOHOL; SMOKING;

D O I：

10.1186/s12964-023-01365-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oropharyngeal cancer, a subset of head and neck cancer, is increasingly recognized as a unique clinical entity primarily influenced by high-risk human papillomavirus (HPV) infections, particularly HPV-16. This review delves into the viral life cycle of HPV-16 and its interactions with host cells, with a specific focus on the crucial roles played by the viral oncoproteins E6 and E7. These oncoproteins drive cellular proliferation by targeting critical tumor suppressor proteins like p53 and Rb, resulting in uncontrolled cell growth and genomic instability. Furthermore, the significance of epigenetic modifications induced by HPV-16 and their implications is important for cancer progression. This comprehensive review provides valuable insights into the intricate molecular landscape of HPV-induced oropharyngeal cancer, shedding light on the development of targeted therapies and preventive strategies for this emerging global health concern.9UR6kKLKRt95gq7eLVP43VVideo Abstract

引用

页数：10

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