Chitosan-maleic acid conjugate as potential excipient candidate for oral drug delivery?

被引：4

作者：

Armengol, Eva Sanchez ^{[1
]}

Knoll, Patrick ^{[1
]}

Hupfauf, Andrea ^{[2
]}

Gust, Ronald ^{[2
]}

Laffleur, Flavia ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Pharm, Ctr Chem & Biomed, Dept Pharmaceut Technol, Innrain 80-82, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Inst Pharm, Ctr Chem & Biomed, Dept Pharmaceut Chem, Innrain 80-82, A-6020 Innsbruck, Austria

来源：

FUTURE MEDICINAL CHEMISTRY | 2023年 / 15卷 / 03期

关键词：

chitosan; cytotoxicity; maleic acid; mucoadhesion; rotating cylinder; texture analyzer; IN-VITRO;

D O I：

10.4155/fmc-2022-0258

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: To develop and evaluate chitosan-maleic acid conjugate. Methods: Maleic anhydride was attached to chitosan backbone via amide bond formation resulting in chitosan-maleic acid. After characterization of the product via H-1 nuclear magnetic resonance, attenuated total reflectance-Fourier transform IR spectroscopy and 2,4,6-trinitrobenzenesulfonic acid assay, examination of mucoadhesion assessment was carried out. Results: The conjugate presented 44.91% modification and no toxicity could be observed after 1 day of incubation. Mucoadhesive properties exhibited 40.97-fold, 13.31-fold and 9.07-fold increase in elastic modulus, dynamic viscosity and viscous modulus, respectively. Moreover, detachment time was increased in 44.44-fold. Conclusion: Chitosan-maleic acid demonstrated enhanced in mucoadhesive properties resulting in biocompatibility. Therefore, potent candidates as polymeric excipients for oral drug delivery could be developed over corresponding chitosan.

引用

页码：241 / 253

页数：13

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