Using Wastewater Surveillance to Compare COVID-19 Outbreaks during the Easter Holidays over a 2-Year Period in Cape Town, South Africa

被引：2

作者：

Mahlangeni, Nomfundo ^{[1
]}

Street, Renee ^{[1
,2
]}

Horn, Suranie ^{[3
]}

Mathee, Angela ^{[1
,2
]}

Mangwana, Noluxabiso ^{[4
,5
]}

Dias, Stephanie ^{[4
]}

Sharma, Jyoti Rajan ^{[4
]}

Ramharack, Pritika ^{[4
,6
]}

Louw, Johan ^{[4
,7
]}

Reddy, Tarylee ^{[8
]}

Surujlal-Naicker, Swastika ^{[9
]}

Nkambule, Sizwe ^{[1
]}

Webster, Candice ^{[1
]}

Mdhluli, Mongezi ^{[10
]}

Gray, Glenda ^{[11
]}

Muller, Christo ^{[4
,5
,12
]}

Johnson, Rabia ^{[4
,12
]}

机构：

[1] South African Med Res Council SAMRC, Environm & Hlth Res Unit, ZA-2028 Johannesburg, South Africa

[2] Univ Johannesburg, Fac Hlth Sci, Environm Hlth Dept, ZA-2028 Johannesburg, South Africa

[3] North West Univ, Occupat Hyg & Hlth Res Initiat, ZA-2531 Potchefstroom, South Africa

[4] South African Med Res Council SAMRC, Biomed Res & Innovat Platform BRIP, ZA-7505 Tygerberg, South Africa

[5] Stellenbosch Univ, Dept Microbiol, ZA-7600 Stellenbosch, South Africa

[6] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Pharmaceut Sci, Westville Campus, ZA-4001 Durban, South Africa

[7] Univ Zululand, Dept Biochem & Microbiol, ZA-3886 Kwa Dlangezwa, South Africa

[8] South African Med Res Council SAMRC, Biostat Res Unit, ZA-4091 Durban, South Africa

[9] City Cape Town Metropolitan Municipal, Water & Sanitat Dept, Sci Serv, ZA-8000 Cape Town, South Africa

[10] South African Med Res Council SAMRC, Chief Res Operat Off, ZA-7050 Tygerberg, South Africa

[11] South African Med Res Council SAMRC, Off President, ZA-7050 Tygerberg, South Africa

[12] Stellenbosch Univ, Fac Med & Hlth Sci, Ctr Cardio Metab Res Africa, Div Med Physiol, ZA-7600 Stellenbosch, South Africa

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 01期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

SARS-CoV-2; wastewater surveillance; Easter holidays; wastewater treatment plants; SARS-COV-2; MOBILITY;

D O I：

10.3390/v15010162

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Wastewater surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown to be an important approach to determine early outbreaks of infections. Wastewater-based epidemiology (WBE) is regarded as a complementary tool for monitoring SARS-CoV-2 trends in communities. In this study, the changes in the SARS-CoV-2 RNA levels in wastewater during Easter holidays in 2021 and 2022 in the City of Cape Town were monitored over nine weeks. Our findings showed a statistically significant difference in the SARS-CoV-2 RNA viral load between the study weeks over the Easter period in 2021 and 2022, except for study week 1 and 4. During the Easter week, 52% of the wastewater treatment plants moved from the lower (low viral RNA) category in 2021 to the higher (medium to very high viral RNA) categories in 2022. As a result, the median SARS-CoV-2 viral loads where higher during the Easter week in 2022 than Easter week in 2021 (p = 0.0052). Mixed-effects model showed an association between the SARS-CoV-2 RNA viral loads and Easter week over the Easter period in 2021 only (p < 0.01). The study highlights the potential of WBE to track outbreaks during the holiday period.

引用

页数：10

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