Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis

被引：19

作者：

Michailidou, Despina ^{[1
]}

Kuley, Runa ^{[1
,2
]}

Wang, Ting ^{[1
]}

Hermanson, Payton ^{[1
]}

Grayson, Peter C. ^{[3
]}

Cuthbertson, David ^{[4
]}

Khalidi, Nader A. ^{[5
]}

Koening, Curry L. ^{[6
]}

Langford, Carol A. ^{[7
]}

McAlear, Carol A. ^{[8
]}

Moreland, Larry W. ^{[9
]}

Pagnoux, Christian ^{[10
]}

Seo, Philip ^{[11
]}

Specks, Ulrich ^{[12
]}

Sreih, Antoine G. ^{[8
]}

Warrington, Kenneth J. ^{[13
]}

Monach, Paul A. ^{[14
]}

Merkel, Peter A. ^{[8
]}

Lood, Christian ^{[1
,15
]}

机构：

[1] Univ Washington, Div Rheumatol, Seattle, WA USA

[2] Mahindra Univ, Ctr Life Sci, Hyderabad, India

[3] Natl Inst Arthrit & Musculoskeletal & Skin Dis, Syst Autoimmun Branch, Bethesda, MD USA

[4] Univ S Florida, Hlth Informat Inst, South Florida, FL USA

[5] Mc Master Univ, Div Rheumatol, Hamilton, ON, Canada

[6] UT Hlth Austin, Div Rheumatol, Austin, TX USA

[7] Cleveland Clin, Div Rheumatol, Cleveland, OH USA

[8] Univ Penn, Div Rheumatol, Philadelphia, PA USA

[9] Univ Colorado, Div Rheumatol & Clin Immunol, Denver, CO USA

[10] Mt Sinai Hosp, Div Rheumatol, Toronto, ON, Canada

[11] Johns Hopkins Univ, Div Rheumatol, Baltimore, MD USA

[12] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA

[13] Mayo Clin, Div Rheumatol, Rochester, MN USA

[14] Brigham & Womens Hosp, Div Rheumatol, Boston, MA USA

[15] Univ Washington, Dept Med, Div Rheumatol, 750 Republican St, Seattle, WA 98109 USA

来源：

CLINICAL IMMUNOLOGY | 2023年 / 249卷

关键词：

Anti-neutrophil cytoplasmic antibody; associated vasculitis; Large vessel vasculitis; Neutrophils; Neutrophil extracellular traps; Histone; Platelet activation; Thrombospondin-1; ANTIHISTONE ANTIBODIES; GRANULOMATOSIS; ACTIVATION; RISK; NETS;

D O I：

10.1016/j.clim.2023.109274

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Levels of neutrophil extracellular traps (NETs) were measured in plasma of healthy controls (HC, n = 30) and patients with granulomatosis with polyangiitis (GPA, n = 123), microscopic polyangiitis (MPA, n = 61), Takayasu's arteritis (TAK, n = 58), and giant cell arteritis (GCA, n = 68), at times of remission or activity and correlated with levels of the platelet-derived thrombospondin-1 (TSP-1).Levels of NETs were elevated during active disease in patients with GPA (p < 0.0001), MPA (p = 0.0038), TAK (p < 0.0001), and GCA (p < 0.0001), and in remission for GPA, p < 0.0001, MPA, p = 0.005, TAK, p = 0.03, and GCA, p = 0.0009. All cohorts demonstrated impaired NET degradation. Patients with GPA (p = 0.0045) and MPA (p = 0.005) had anti-NET IgG antibodies. Patients with TAK had anti-histone antibodies (p < 0.01), correlating with presence of NETs. Levels of TSP-1 were increased in all patients with vasculitis, and associated with NET formation.NET formation is a common process in vasculitides. Targeting NET formation or degradation could be po-tential therapeutic approaches for vasculitides.

引用

页数：10

共 54 条

[41] Enhanced Formation and Disordered Regulation of NETs in Myeloperoxidase-ANCA-Associated Microscopic Polyangiitis [J].