Understanding COVID-19-associated endothelial dysfunction: role of PIEZO1 as a potential therapeutic target

被引：1
作者：
Zhang, Xiaoting [1 ]
Liu, Jinhai [1 ]
Deng, Xiaoming [1 ]
Bo, Lulong [1 ]
机构：
[1] Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词：
COVID-19; SARS-CoV-2; endothelial dysfunction; immunothrombosis; PIEZO1; therapeutic target; CHANNEL PIEZO1; BLOOD-PRESSURE; ACE2; RECEPTOR; ACTIVATION; SARS-COV-2; COVID-19; ANGIOTENSIN-(1-7); INFLAMMATION;
D O I：
10.3389/fimmu.2024.1281263
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Due to its high infectivity, the pandemic has rapidly spread and become a global health crisis. Emerging evidence indicates that endothelial dysfunction may play a central role in the multiorgan injuries associated with COVID-19. Therefore, there is an urgent need to discover and validate novel therapeutic strategies targeting endothelial cells. PIEZO1, a mechanosensitive (MS) ion channel highly expressed in the blood vessels of various tissues, has garnered increasing attention for its potential involvement in the regulation of inflammation, thrombosis, and endothelial integrity. This review aims to provide a novel perspective on the potential role of PIEZO1 as a promising target for mitigating COVID-19-associated endothelial dysfunction.
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  • [91] Chemical activation of the mechanotransduction channel Piezo1
    Syeda, Ruhma
    Xu, Jie
    Dubin, Adrienne E.
    Coste, Bertrand
    Mathur, Jayanti
    Truc Huynh
    Matzen, Jason
    Lao, Jianmin
    Tully, David C.
    Engels, Ingo H.
    Petrassi, H. Michael
    Schumacher, Andrew M.
    Montal, Mauricio
    Bandell, Michael
    Patapoutian, Ardem
    [J]. ELIFE, 2015, 4
  • [92] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19
    Szabo, Peter A.
    Dogra, Pranay
    Gray, Joshua, I
    Wells, Steven B.
    Connors, Thomas J.
    Weisberg, Stuart P.
    Krupska, Izabela
    Matsumoto, Rei
    Poon, Maya M. L.
    Idzikowski, Emma
    Morris, Sinead E.
    Pasin, Chloe
    Yates, Andrew J.
    Ku, Amy
    Chait, Michael
    Davis-Porada, Julia
    Guo, Xinzheng, V
    Zhou, Jing
    Steinle, Matthew
    Mackay, Sean
    Saqi, Anjali
    Baldwin, Matthew R.
    Sims, Peter A.
    Farber, Donna L.
    [J]. IMMUNITY, 2021, 54 (04) : 797 - +
  • [93] The Form and Function of PIEZO2
    Szczot, Marcin
    Nickolls, Alec R.
    Lam, Ruby M.
    Chesler, Alexander T.
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021, 2021, 90 : 507 - 534
  • [94] COVID-19 and heart failure: from infection to inflammation and angiotensinIIstimulation. Searching for evidence from a new disease
    Tomasoni, Daniela
    Italia, Leonardo
    Adamo, Marianna
    Inciardi, Riccardo M.
    Lombardi, Carlo M.
    Solomon, Scott D.
    Metra, Marco
    [J]. EUROPEAN JOURNAL OF HEART FAILURE, 2020, 22 (06) : 957 - 966
  • [95] Long COVID: pathophysiological factors and abnormalities of coagulation
    Turner, Simone
    Khan, M. Asad
    Putrino, David
    Woodcock, Ashley
    Kell, Douglas B.
    Pretorius, Etheresia
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2023, 34 (06) : 321 - 344
  • [96] The glycocalyx: a novel diagnostic and therapeutic target in sepsis
    Uchimido, Ryo
    Schmidt, Eric P.
    Shapiro, Nathan I.
    [J]. CRITICAL CARE, 2019, 23 (1):
  • [97] Endothelial cell infection and endotheliitis in COVID-19
    Varga, Zsuzsanna
    Flammer, Andreas J.
    Steiger, Peter
    Haberecker, Martina
    Andermatt, Rea
    Zinkernagel, Annelies S.
    Mehra, Mandeep R.
    Schuepbach, Reto A.
    Ruschitzka, Frank
    Moch, Holger
    [J]. LANCET, 2020, 395 (10234) : 1417 - 1418
  • [98] Lactate Kinetics Reflect Organ Dysfunction and Are Associated with Adverse Outcomes in Intensive Care Unit Patients with COVID-19 Pneumonia: Preliminary Results from a GREEK Single-Centre Study
    Vassiliou, Alice G.
    Jahaj, Edison
    Ilias, Ioannis
    Markaki, Vassiliki
    Malachias, Sotirios
    Vrettou, Charikleia
    Ischaki, Eleni
    Mastora, Zafeiria
    Douka, Evangelia
    Keskinidou, Chrysi
    Tsipilis, Stamatios
    Vassiliadi, Dimitra A.
    Kotanidou, Anastasia
    Dimopoulou, Ioanna
    [J]. METABOLITES, 2020, 10 (10) : 1 - 12
  • [99] Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients
    Velavan, Thirumalaisamy P.
    Le Thi Kieu Linh
    Kreidenweiss, Andrea
    Gabor, Julian
    Krishna, Sanjeev
    Kremsner, Peter G.
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2021, 104 (03) : 1041 - 1044
  • [100] SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology
    Veras, Flavio Protasio
    Pontelli, Marjorie Cornejo
    Silva, Camila Meirelles
    Toller-Kawahisa, Juliana E.
    de Lima, Mikhael
    Nascimento, Daniele Carvalho
    Schneider, Ayda Henriques
    Caetite, Diego
    Tavares, Lucas Alves
    Paiva, Isadora M.
    Rosales, Roberta
    Colon, David
    Martins, Ronaldo
    Castro, Italo Araujo
    Almeida, Glaucia M.
    Fernandes Lopes, Maria Isabel
    Benatti, Maira Nilson
    Bonjorno, Leticia Pastorelli
    Giannini, Marcela Cavichioli
    Luppino-Assad, Rodrigo
    Almeida, Sergio Luna
    Vilar, Fernando
    Santana, Rodrigo
    Bollela, Valdes R.
    Auxiliadora-Martins, Maria
    Borges, Marcos
    Miranda, Carlos Henrique
    Pazin-Filho, Antonio
    da Silva, Luis Lamberti P.
    Cunha, Larissa Dias
    Zamboni, Dario S.
    Dal-Pizzol, Felipe
    Leiria, Luiz O.
    Li Siyuan
    Batah, Sabrina
    Fabro, Alexandre
    Mauad, Thais
    Dolhnikoff, Marisa
    Duarte-Neto, Amaro
    Saldiva, Paulo
    Cunha, Thiago Mattar
    Alves-Filho, Jose Carlos
    Arruda, Eurico
    Louzada-Junior, Paulo
    Oliveira, Rene Donizeti
    Cunha, Fernando Queiroz
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 217 (12)
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