Understanding COVID-19-associated endothelial dysfunction: role of PIEZO1 as a potential therapeutic target

被引：1
作者：
Zhang, Xiaoting [1 ]
Liu, Jinhai [1 ]
Deng, Xiaoming [1 ]
Bo, Lulong [1 ]
机构：
[1] Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词：
COVID-19; SARS-CoV-2; endothelial dysfunction; immunothrombosis; PIEZO1; therapeutic target; CHANNEL PIEZO1; BLOOD-PRESSURE; ACE2; RECEPTOR; ACTIVATION; SARS-COV-2; COVID-19; ANGIOTENSIN-(1-7); INFLAMMATION;
D O I：
10.3389/fimmu.2024.1281263
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Due to its high infectivity, the pandemic has rapidly spread and become a global health crisis. Emerging evidence indicates that endothelial dysfunction may play a central role in the multiorgan injuries associated with COVID-19. Therefore, there is an urgent need to discover and validate novel therapeutic strategies targeting endothelial cells. PIEZO1, a mechanosensitive (MS) ion channel highly expressed in the blood vessels of various tissues, has garnered increasing attention for its potential involvement in the regulation of inflammation, thrombosis, and endothelial integrity. This review aims to provide a novel perspective on the potential role of PIEZO1 as a promising target for mitigating COVID-19-associated endothelial dysfunction.
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页数：12
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共 125 条
  • [1] Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
    Ackermann, Maximilian
    Verleden, Stijn E.
    Kuehnel, Mark
    Haverich, Axel
    Welte, Tobias
    Laenger, Florian
    Vanstapel, Arno
    Werlein, Christopher
    Stark, Helge
    Tzankov, Alexandar
    Li, William W.
    Li, Vincent W.
    Mentzer, Steven J.
    Jonigk, Danny
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (02) : 120 - 128
  • [2] Antibody-induced procoagulant platelets in severe COVID-19 infection
    Althaus, Karina
    Marini, Irene
    Zlamal, Jan
    Pelzl, Lisann
    Singh, Anurag
    Haberle, Helene
    Mehrlander, Martin
    Hammer, Stefanie
    Schulze, Harald
    Bitzer, Michael
    Malek, Nisar
    Rath, Dominik
    Bosmuller, Hans
    Nieswandt, Bernard
    Gawaz, Meinrad
    Bakchoul, Tamam
    Rosenberger, Peter
    [J]. BLOOD, 2021, 137 (08) : 1061 - 1071
  • [3] Altmann DM, 2023, NAT REV IMMUNOL, V23, P618, DOI 10.1038/s41577-023-00904-7
  • [4] Long COVID: 3 years in
    不详
    [J]. LANCET, 2023, 401 (10379) : 795 - 795
  • [5] The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
    Bae, Chilman
    Sachs, Frederick
    Gottlieb, Philip A.
    [J]. BIOCHEMISTRY, 2011, 50 (29) : 6295 - 6300
  • [6] Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
    Bartoli, Fiona
    Debant, Marjolaine
    Chuntharpursat-Bon, Eulashini
    Evans, Elizabeth L.
    Musialowski, Katie E.
    Parsonage, Gregory
    Morley, Lara C.
    Futers, T. Simon
    Sukumar, Piruthivi
    Bowen, T. Scott
    Kearney, Mark T.
    Lichtenstein, Laeticia
    Roberts, Lee D.
    Beech, David J.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (05)
  • [7] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
    Bonaventura, Aldo
    Vecchie, Alessandra
    Dagna, Lorenzo
    Martinod, Kimberly
    Dixon, Dave L.
    Van Tassell, Benjamin W.
    Dentali, Francesco
    Montecucco, Fabrizio
    Massberg, Steffen
    Levi, Marcel
    Abbate, Antonio
    [J]. NATURE REVIEWS IMMUNOLOGY, 2021, 21 (05) : 319 - 329
  • [8] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
    Brevini, Teresa
    Maes, Mailis
    Webb, Gwilym J.
    John, Binu, V
    Fuchs, Claudia D.
    Buescher, Gustav
    Wang, Lu
    Griffiths, Chelsea
    Brown, Marnie L.
    Scott, William E., III
    Pereyra-Gerber, Pehuen
    Gelson, William T. H.
    Brown, Stephanie
    Dillon, Scott
    Muraro, Daniele
    Sharp, Jo
    Neary, Megan
    Box, Helen
    Tatham, Lee
    Stewart, James
    Curley, Paul
    Pertinez, Henry
    Forrest, Sally
    Mlcochova, Petra
    Varankar, Sagar S.
    Darvish-Damavandi, Mahnaz
    Mulcahy, Victoria L.
    Kuc, Rhoda E.
    Williams, Thomas L.
    Heslop, James A.
    Rossetti, Davide
    Tysoe, Olivia C.
    Galanakis, Vasileios
    Vila-Gonzalez, Marta
    Crozier, Thomas W. M.
    Bargehr, Johannes
    Sinha, Sanjay
    Upponi, Sara S.
    Fear, Corrina
    Swift, Lisa
    Saeb-Parsy, Kourosh
    Davies, Susan E.
    Wester, Axel
    Hagstrom, Hannes
    Melum, Espen
    Clements, Darran
    Humphreys, Peter
    Herriott, Jo
    Kijak, Edyta
    Cox, Helen
    [J]. NATURE, 2023, 615 (7950) : 134 - +
  • [9] Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity
    Briquez, Priscilla S.
    Rouhani, Sherin J.
    Yu, Jovian
    Pyzer, Athalia R.
    Trujillo, Jonathan
    Dugan, Haley L.
    Stamper, Christopher T.
    Changrob, Siriruk
    Sperling, Anne, I
    Wilson, Patrick C.
    Gajewski, Thomas F.
    Hubbell, Jeffrey A.
    Swartz, Melody A.
    [J]. SCIENCE ADVANCES, 2022, 8 (40)
  • [10] Cardiac complications in patients with COVID-19: a systematic review
    Brogi, E.
    Marino, F.
    Bertini, P.
    Tavazzi, G.
    Corradi, F.
    Forfori, F.
    [J]. JOURNAL OF ANESTHESIA ANALGESIA AND CRITICAL CARE, 2022, 2 (01):
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