Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs

被引：1

作者：

Zhao, Jinlu ^{[1
]}

Li, Guodong ^{[1
]}

Ren, Yi ^{[1
]}

Zhang, Zhicheng ^{[1
]}

Chen, Hongsheng ^{[1
]}

Zhang, Haopeng ^{[1
]}

Zhao, Xingyu ^{[1
]}

Li, Wang ^{[1
]}

Jia, Yucheng ^{[1
]}

Guan, Xue ^{[1
]}

Liu, Ming ^{[1
,2
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 4, Dept Gen Surg, Harbin 150001, Peoples R China

来源：

ANTI-CANCER DRUGS | 2023年 / 34卷 / 10期

基金：

中国国家自然科学基金;

关键词：

colorectal carcinoma; ellagic acid; long noncoding RNA; mRNA; EXPRESSION PROFILE; CARCINOMA CELLS; LNCRNA; MIGRATION; INVASION; CODES;

D O I：

10.1097/CAD.0000000000001513

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The natural phenolic compound ellagic acid exerts anti-cancer effects, including activity against colorectal cancer (CRC). Previously, we reported that ellagic acid can inhibit the proliferation of CRC, and can induce cell cycle arrest and apoptosis. This study investigated ellagic acid-mediated anticancer effects using the human colon cancer HCT-116 cell line. After 72 h of ellagic acid treatment, a total of 206 long noncoding RNAs (lncRNAs) with differential expression greater than 1.5-fold were identified (115 down-regulated and 91 up-regulated). Furthermore, the co-expression network analysis of differentially expressed lncRNA and mRNA showed that differential expressed lncRNA might be the target of ellagic acid activity in inhibiting CRC.

引用

页码：1112 / 1121

页数：10

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