The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review

被引：5
作者：
Giuffre, Mauro [1 ]
Merli, Nicola [2 ]
Pugliatti, Maura [2 ,3 ]
Moretti, Rita [4 ]
机构：
[1] Yale Sch Med, Dept Internal Med Digest Dis, New Haven, CT 06511 USA
[2] Univ Ferrara, Dept Neurosci & Rehabil, I-44124 Ferrara, Italy
[3] Univ Ferrara, Interdept Res Ctr Multiple Sclerosis & Other Infla, I-44124 Ferrara, Italy
[4] Univ Trieste, Dept Clin Med & Surg Sci, I-34149 Trieste, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 06期
关键词：
NAFLD; NASH; insulin resistance; diabetes; gut microbiota; inflammation; gut-liver-brain axis; vitamins; free fatty acids; dementia; cognitive impairment; Alzheimer's disease; neurodegeneration; hyperammonemia; vitamin A; vitamin B; vitamin D; MIDDLE-AGED ADULTS; BRAIN-BARRIER PERMEABILITY; VITAMIN-D; DEMENTIA PREVENTION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; TRANSGENIC MICE; GUT MICROBIOTA; FOLIC-ACID; IMPAIRMENT;
D O I：
10.3390/ijms25063337
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific research nowadays extends to different levels, exploring NAFLD's putative proinflammatory mechanism of such dysmetabolic conditions, spreading out from the liver to a multisystemic involvement. The aim of this review is to analyze the most recent scientific literature on cognitive involvement in NAFLD, as well as understand its underlying potential background processes, i.e., neuroinflammation, the role of microbiota in the brain-liver-gut axis, hyperammonemia neurotoxicity, insulin resistance, free fatty acids, and vitamins.
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页数：23
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