K2CO3-promoted synthesis of amides from 1-aryl-2,2,2-trifluoroethanones and amines under mild conditions

被引：6

作者：

Zhong, Pinyong ^{[1
]}

Wang, Yu-Chao ^{[1
]}

Liu, Jin-Biao ^{[1
]}

Zhang, Linjun ^{[2
]}

Luo, Nianhua ^{[3
]}

机构：

[1] Jiangxi Univ Sci & Technol, Jiangxi Prov Key Lab Funct Mol Mat Chem, Ganzhou 341000, Peoples R China

[2] Jiangxi Prov Zhonggantou Survey & Design Co Ltd, Nanchang 330029, Peoples R China

[3] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Peoples R China

来源：

RSC ADVANCES | 2023年 / 13卷 / 26期

基金：

中国国家自然科学基金;

关键词：

C BOND-CLEAVAGE; ONE-POT; OXIDATIVE AMIDATION; SIMPLE KETONES; HALLER-BAUER; ACID; ALDEHYDES; SOLVENT; ESTERS; CONVERSION;

D O I：

10.1039/d3ra03329e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A base-promoted amidation of 1-aryl-2,2,2-trifluoroethanones with amines via Haller-Bauer reaction has been developed. In this reaction, the direct transformation of 1-aryl-2,2,2-trifluoroethanones into amides via C(O)-C bond cleavage occurs without the use of any stoichiometric chemical oxidants or transition-metal catalysts. A series of primary and secondary amines are shown to be compatible with this transformation, and several pharmaceutical molecules were synthesized.

引用

页码：18160 / 18164

页数：5

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