Prevalence and Long-term Outcomes of CT Interstitial Lung Abnormalities in a Health Screening Cohort

被引：36

作者：

Lee, Jong Eun ^{[1
]}

Chae, Kum Ju ^{[3
]}

Suh, Young Ju ^{[4
]}

Jeong, Won Gi ^{[5
]}

Lee, Taebum ^{[2
]}

Kim, Yun-Hyeon ^{[1
]}

Jin, Gong Yong ^{[3
]}

Jeong, Yeon Joo ^{[6
,7
]}

机构：

[1] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Radiol, Gwangju, South Korea

[2] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Pathol, Gwangju, South Korea

[3] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med,Dept Radiol, Jeonju, South Korea

[4] Inha Univ, Sch Med, Dept Biomed Sci, Incheon, South Korea

[5] Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Radiol, Hwasun, South Korea

[6] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Biomed Res Inst,Dept Radiol, Pusan, South Korea

[7] Pusan Natl Univ, Sch Med, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol,Dept Rad, 20 Geumo Ro, Yangsan Si 50612, South Korea

来源：

RADIOLOGY | 2023年 / 306卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

PROGRESSION; EMPHYSEMA;

D O I：

10.1148/radiol.221172

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background: The association between interstitial lung abnormalities (ILAs) and long-term outcomes has not been reported in Asian health screening populations. Purpose: To investigate ILA prevalence in an Asian health screening cohort and determine rates and risks for ILA progression, lung cancer development, and mortality within the 10-year follow-up. Materials and Methods: This observational, retrospective multicenter study included patients aged 50 years or older who underwent chest CT at three health screening centers over a 4-year period (2007-2010). ILA status was classified as none, equivocal ILA, and ILA (nonfibrotic or fibrotic). Progression was evaluated from baseline to the last follow-up CT examination, when available. The log-rank test was performed to compare mortality rates over time between ILA statuses. Multivariable Cox proportional hazards models were used to assess factors associated with hazards of ILA progression, lung cancer development, and mortality. Results: Of the 2765 included patients (mean age, 59 years +/- 7 [SD]; 2068 men), 94 (3%) had a finding of ILA (35 nonfibrotic and 59 fibrotic ILA) and 119 (4%) had equivocal ILA. The median time for CT follow-up and the entire observation was 8 and 12 years, respectively. ILA progression was observed in 80% (48 of 60) of patients with ILA over 8 years. Those with fibrotic and nonfibrotic ILA had a higher mortality rate than those without ILA (P < .001 and P = .01, respectively) over 12 years. Fibrotic ILA was independently associated with ILA progression (hazard ratio [HR], 10.3; 95% CI: 6.4, 16.4; P < .001), lung cancer development (HR, 4.4; 95% CI: 2.1, 9.1; P < .001), disease-specific mortality (HR, 6.7; 95% CI: 3.7, 12.2; P < .001), and all-cause mortality (HR, 2.5; 95% CI: 1.6, 3.8; P < .001) compared with no ILA. Conclusion: The prevalence of interstitial lung abnormalities (ILAs) in an Asian health screening cohort was approximately 3%, and fibrotic ILA was an independent risk factor for ILA progression, lung cancer development, and mortality. (c) RSNA, 2022

引用

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