Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation

被引:0
作者
Adeyanju, Anne A. [1 ]
Oyenihi, Omolola R. [2 ]
Oguntibeju, Oluwafemi O. [2 ]
Ojomu, Oreoluwa [3 ]
机构
[1] Koladaisi Univ, Fac Appl Sci, Dept Biol Sci, Ibadan, Nigeria
[2] Cape Peninsula Univ Technol, Fac Hlth & Wellness Sci, Dept Biomed Sci, Phytomed & Phytochem Grp, Bellville, South Africa
[3] Bowen Univ, Dept Biochem, Iwo, Nigeria
关键词
Sildenafil; aggravates; adriamycin; testicular toxicity; IMPROVES ERECTILE FUNCTION; CITRATE IMPROVES; PROSTATE-CANCER; P-GLYCOPROTEIN; DOXORUBICIN; CHEMOTHERAPY; INHIBITORS; DYSFUNCTION; DAMAGE; MOUSE;
D O I
10.1080/01480545.2021.2018455
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Male reproductive toxicity is a well-established side effect of the chemotherapeutic drug adriamycin (ADR). Sildenafil (SIL) is a phosphodiesterase inhibitor known to enhance the chemosensitivity of cancer cells to ADR. However, there is a scarcity of information on the effect of SIL on ADR-induced testicular toxicity. In this study, SIL (5, 10, or 20 mg/kg/day) was administered to male rats for 7 days, followed by a single intraperitoneal injection of ADR (20 mg/kg) on day 7. Control rats received either ADR, SIL, or normal saline for 7 days. Epididymal sperm were collected from the testes to assess the effects on sperm quality, quantity, and serum testosterone concentration was also determined. ADR treatment caused a decrease in sperm motility and elevated the percentage of sperms with tail defects which worsened in combination with SIL (20 mg/kg). Furthermore, ADR alone or in combination with SIL dose-dependently increased total sperm abnormalities. SIL (20 mg/kg) plus ADR also decreased sperm count and lowered testosterone level compared to ADR-only rats. In conclusion, exposure of rats to SIL before ADR treatment has the potential to worsen ADR-induced testicular toxicity.
引用
收藏
页码:219 / 225
页数:7
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