Single cell multi-omic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma

被引:0
|
作者
Harrison, Simon [1 ,2 ]
Riley, Caroline Hasselbalch [3 ]
Manier, Salomon [4 ]
Yoon, Sung-Soo [5 ]
Pinto, Antonio [6 ]
Cazaubiel, Titouan [7 ]
Guidetti, Anna [8 ]
Popat, Rakesh [9 ]
Touzeau, Cyrille [10 ]
Ocio, Enrique [11 ]
Offner, Fritz [12 ]
Rodriguez-Otero, Paula [13 ]
Rizzello, Ilaria [14 ,15 ]
Mateos, Maria-Victoria [16 ]
Broeske, Ann-Marie [17 ]
Dekhtiarenko, Iryna [18 ]
Dimier, Natalie [19 ]
Eckmann, Jan [17 ]
Helms, Hans-Joachin [20 ]
Jacob, Wolfgang [17 ]
Schneider, Meike [20 ]
Sleiman, Nassim [20 ]
Weisser, Martin [17 ]
Carlo-Stella, Carmelo [21 ,22 ]
机构
[1] Univ Melbourne, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[2] Univ Melbourne, Royal Melbourne Hosp, Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
[3] Rigshospitalet, Copenhagen, Denmark
[4] CHU Lille, Lille, France
[5] Seoul Natl Univ, Coll Med, Seoul, South Korea
[6] Ist Nazl Tumori IRCCS Fondazione G Pascale, Naples, Italy
[7] CHU Bordeaux, Bordeaux, France
[8] Ist Nazl Tumori, Milan, Italy
[9] NHS Univ Coll London Hosp, London, England
[10] CHU Nantes, Nantes, France
[11] Marques Valdecilla Univ Hosp, Santander, Spain
[12] Univ Ziekenhuis Gent, Ghent, Belgium
[13] Clin Univ Navarra, CIMA, CIBERONC, IDISNA, Pamplona, Spain
[14] Univ Bologna, Ist Ematol Seragnoli, IRCCS Azienda Osped, Bologna, Italy
[15] Univ Bologna, Bologna, Italy
[16] Univ Hosp Salamanca, IBSAL, CIC, CIBERONC, Salamanca, Spain
[17] Roche Innovat Ctr Munich, Penzberg, Germany
[18] Roche Innovat Ctr Zurich, Zurich, Switzerland
[19] Roche Innovat Ctr Welwyn, Welwyn Garden City, England
[20] Roche Innovat Ctr Basel, Basel, Switzerland
[21] Humanitas Univ, Dept Oncol & Hematol, Humanitas Canc Ctr, Humanitas Clin & Res Ctr, Rozzano, Italy
[22] Humanitas Univ, Dept Biomed Sci, Rozzano, Italy
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
OA-04
引用
收藏
页码:S3 / S3
页数:1
相关论文
共 50 条
  • [31] Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (MM)
    Cohen, Adam D.
    Garfall, Alfred L.
    Stadtmauer, Edward A.
    Lacey, Simon F.
    Lancaster, Eric
    Vogl, Dan T.
    Weiss, Brendan M.
    Ambrose, David E.
    Nelson, Anne Marie
    Chen, Fang
    Plesa, Gabriela
    Kulikovskaya, Irina
    Gonzalez, Vanessa
    Gupta, Minnal
    Young, Regina M.
    Dengel, Karen
    O'keefe, Laura
    Le, Samantha
    Richardson, Celeste
    Isaacs, Randi E.
    Melenhorst, J. Joseph
    Levine, Bruce L.
    June, Carl H.
    Milone, Michael C.
    BLOOD, 2017, 130
  • [32] Population Pharmacokinetics of Orvacabtagene Autoleucel, an Autologous BCMA-Directed Chimeric Antigen Receptor T-cell Product, in Patients with Relapsed/Refractory Multiple Myeloma
    Hu, Hongxiang
    Li, Yan
    Piasecki, Julia
    Hosseyni, Daniela
    Yan, Zhicheng
    Liu, Xianghong
    Ogasawara, Ken
    Zhou, Simon
    Cheng, Yiming
    CLINICAL CANCER RESEARCH, 2025, 31 (06) : 1163 - 1171
  • [33] B cell maturation antigen-specific chimeric antigen receptor T cells for relapsed or refractory multiple myeloma: A meta-analysis
    Gagelmann, Nico
    Ayuk, Francis
    Atanackovic, Djordje
    Kroeger, Nicolaus
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2020, 104 (04) : 318 - 327
  • [34] Allogeneic chimeric antigen receptor T-cells and multiple myeloma
    Malard, Florent
    HEMATOLOGIE, 2021, 27 : 13 - 18
  • [35] Cytotoxicity and exhaustion markers of chimeric antigen receptor T cells targeting BCMA in multiple myeloma cell lines between patients and healthy donors
    Prasongtanakij, Somsak
    Preedagasamzin, Sarinthip
    Jittorntrum, Bunyada
    Anurathapan, Usanarat
    Puavilai, Teeraya
    Niparuck, Pimjai
    Chantrathammachart, Pichika
    Piyajaroenkij, Thanakrit
    Uaesoontrachoon, Kitipong
    Uchibori, Ryosuke
    Ozawa, Keiya
    Ohmine, Ken
    Hongeng, Suradej
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2024, 112 (02) : 248 - 256
  • [36] Chimeric antigen receptor T-cell therapy for multiple myeloma
    Wang, Zehua
    Chen, Chen
    Wang, Lei
    Jia, Yongxu
    Qin, Yanru
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [37] Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma
    Hosen, Naoki
    CANCERS, 2019, 11 (12)
  • [38] Chimeric antigen receptor T-cell therapy for multiple myeloma
    Hosen, Naoki
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2020, 111 (04) : 530 - 534
  • [39] Chimeric antigen receptor T-cell therapies for multiple myeloma
    Mikkilineni, Lekha
    Kochenderfer, James N.
    BLOOD, 2017, 130 (24) : 2594 - 2602
  • [40] Chimeric Antigen Receptor T-cell Therapy for Multiple Myeloma
    Atrash, Shebli
    Ali, Syed Abbas
    Usmani, Saad Z.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 (01): : 21 - 34